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Kank1 KN motif and ankyrin repeat domains 1 [ Mus musculus (house mouse) ]

Gene ID: 107351, updated on 8-May-2024

Summary

Official Symbol
Kank1provided by MGI
Official Full Name
KN motif and ankyrin repeat domains 1provided by MGI
Primary source
MGI:MGI:2147707
See related
Ensembl:ENSMUSG00000032702 AllianceGenome:MGI:2147707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ankrd15; mKIAA0172; A930031B09Rik; D330024H06Rik
Summary
Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including glomerular visceral epithelial cell migration; negative regulation of cellular component organization; and regulation of signal transduction. Predicted to be located in nucleus and ruffle membrane. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including alimentary system; central nervous system; craniocervical region bone; limb; and metanephros. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 22.5), ovary adult (RPKM 15.3) and 28 other tissues See more
Orthologs
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Genomic context

See Kank1 in Genome Data Viewer
Location:
19 B; 19 20.33 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (25214146..25411861)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (25236732..25434498)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 8 Neighboring gene STARR-seq mESC enhancer starr_45812 Neighboring gene predicted gene, 34186 Neighboring gene predicted gene, 24252 Neighboring gene STARR-seq mESC enhancer starr_45817 Neighboring gene STARR-seq mESC enhancer starr_45819 Neighboring gene predicted gene, 34432 Neighboring gene predicted gene, 52392 Neighboring gene STARR-seq mESC enhancer starr_45822 Neighboring gene predicted gene, 26207 Neighboring gene predicted gene 5249

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC90826

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lamellipodium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in podocyte cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
KN motif and ankyrin repeat domain-containing protein 1
Names
ankyrin repeat domain 15

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348180.2NP_001335109.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:10801246
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:11601190
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    pfam12796
    Location:11641249
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001404570.1NP_001391499.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238
  3. NM_001404572.1NP_001391501.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238
  4. NM_001404573.1NP_001391502.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238
  5. NM_001404574.1NP_001391503.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
  6. NM_001404575.1NP_001391504.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238
  7. NM_001404576.1NP_001391505.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
    UniProtKB/TrEMBL
    E9Q238
  8. NM_001404577.1NP_001391506.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
  9. NM_001404578.1NP_001391507.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
  10. NM_001404579.1NP_001391508.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
  11. NM_001404580.1NP_001391509.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126944, AC132319
  12. NM_001404581.1NP_001391510.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126944
  13. NM_001404582.1NP_001391511.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC126944
  14. NM_001404583.1NP_001391512.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126944
  15. NM_001404584.1NP_001391513.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126944
  16. NM_001404585.1NP_001391514.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC126944
  17. NM_001404605.1NP_001391534.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC126944
  18. NM_001404607.1NP_001391536.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC126944
  19. NM_001404608.1NP_001391537.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC126944
  20. NM_001404610.1NP_001391539.1  KN motif and ankyrin repeat domain-containing protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC126944
  21. NM_181404.7NP_852069.4  KN motif and ankyrin repeat domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_852069.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC126944, AC132319
    Consensus CDS
    CCDS37944.1
    UniProtKB/TrEMBL
    E9Q238, Q6AXG6
    Related
    ENSMUSP00000042177.9, ENSMUST00000049400.15
    Conserved Domains (4) summary
    COG0666
    Location:11621328
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:12421272
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    pfam12796
    Location:12461331
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    25214146..25411861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526585.3XP_006526648.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006526648.1

    UniProtKB/TrEMBL
    E9Q238, Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:11621328
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:12421272
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    pfam12796
    Location:12461331
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_036161387.1XP_036017280.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    E9Q238, Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:11621328
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:12421272
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    pfam12796
    Location:12461331
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_036161391.1XP_036017284.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:10801246
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:11601190
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:3068
    KN_motif; KN motif
    pfam12796
    Location:11641249
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_030250693.2XP_030106553.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:10041170
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:10841114
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:102330
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:10881173
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_030250692.2XP_030106552.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (4) summary
    COG0666
    Location:10041170
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:10841114
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:102330
    ERM; Ezrin/radixin/moesin family
    pfam12796
    Location:10881173
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_006526590.3XP_006526653.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    E9Q944
    Related
    ENSMUSP00000116660.2, ENSMUST00000146647.3
    Conserved Domains (2) summary
    pfam00769
    Location:288516
    ERM; Ezrin/radixin/moesin family
    pfam12075
    Location:5896
    KN_motif; KN motif
  7. XM_006526586.5XP_006526649.1  KN motif and ankyrin repeat domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    Q6AXG6
    Conserved Domains (5) summary
    COG0666
    Location:11081274
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:11881218
    ANK; ANK repeat [structural motif]
    pfam00769
    Location:288516
    ERM; Ezrin/radixin/moesin family
    pfam12075
    Location:5896
    KN_motif; KN motif
    pfam12796
    Location:11921277
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_004940110.1 RNA Sequence