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TCFL5 transcription factor like 5 [ Homo sapiens (human) ]

Gene ID: 10732, updated on 5-Aug-2022


Official Symbol
TCFL5provided by HGNC
Official Full Name
transcription factor like 5provided by HGNC
Primary source
See related
Ensembl:ENSG00000101190 MIM:604745; AllianceGenome:HGNC:11646
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHA; Figlb; SOSF1; E2BP-1; bHLHe82
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell population proliferation; and spermatogenesis. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Broad expression in testis (RPKM 22.8), thyroid (RPKM 7.1) and 19 other tissues See more
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Genomic context

See TCFL5 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62841005..62861822, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64640566..64661385, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61472357..61493174, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene OGFR antisense RNA 1 Neighboring gene MRG domain binding protein Neighboring gene opioid growth factor receptor Neighboring gene collagen type IX alpha 3 chain Neighboring gene Sharpr-MPRA regulatory region 13411 Neighboring gene diphthamide biosynthesis 3 pseudogene 1 Neighboring gene uncharacterized LOC105372717 Neighboring gene ADP ribosylation factor 4 pseudogene 2 Neighboring gene small nucleolar RNA, H/ACA box 117 Neighboring gene death inducer-obliterator 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transcription factor-like 5 (basic helix-loop-helix) (TCFL5) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC46135

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
located_in male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
located_in nucleus IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
transcription factor-like 5 protein
HPV-16 E2-binding protein 1
cha transcription factor
spermatogenesis- and oogenesis-specific bHLH-containing protein 1
transcription factor-like 5 (basic helix-loop-helix)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301726.2NP_001288655.1  transcription factor-like 5 protein isoform 2

    Status: VALIDATED

    Transcript Variant: This variant (2) uses an alternate in-frame splice site and contains an alternate exon in the 3' coding region, which results in the use of a distinct stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL035669, BC046933, BC065520, BU632218
  2. NM_006602.4NP_006593.2  transcription factor-like 5 protein isoform 1

    See identical proteins and their annotated locations for NP_006593.2

    Status: VALIDATED

    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB012124, AL035669, BC046933, CA419503
    Consensus CDS
    Q9BYW0, Q9UL49
    ENSP00000334294.3, ENST00000335351.8

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    62841005..62861822 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451813.2XP_024307581.1  transcription factor-like 5 protein isoform X9

  2. XM_005260185.5XP_005260242.1  transcription factor-like 5 protein isoform X3

  3. XM_024451812.2XP_024307580.1  transcription factor-like 5 protein isoform X8

  4. XM_047439840.1XP_047295796.1  transcription factor-like 5 protein isoform X11

  5. XM_011528497.4XP_011526799.1  transcription factor-like 5 protein isoform X2

  6. XM_024451808.2XP_024307576.1  transcription factor-like 5 protein isoform X1

    ENSP00000217162.5, ENST00000217162.5
  7. XM_024451810.2XP_024307578.1  transcription factor-like 5 protein isoform X6

  8. XM_047439838.1XP_047295794.1  transcription factor-like 5 protein isoform X5

  9. XM_024451809.2XP_024307577.1  transcription factor-like 5 protein isoform X4

  10. XM_024451811.2XP_024307579.1  transcription factor-like 5 protein isoform X7

  11. XM_047439839.1XP_047295795.1  transcription factor-like 5 protein isoform X10


  1. XR_007067444.1 RNA Sequence

Alternate T2T-CHM13v2.0


  1. NC_060944.1 Alternate T2T-CHM13v2.0

    64640566..64661385 complement
    GenBank, FASTA, Sequence Viewer (Graphics)