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Psat1 phosphoserine aminotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 107272, updated on 7-Apr-2024

Summary

Official Symbol
Psat1provided by MGI
Official Full Name
phosphoserine aminotransferase 1provided by MGI
Primary source
MGI:MGI:2183441
See related
Ensembl:ENSMUSG00000024640 AllianceGenome:MGI:2183441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSA; EPIP; Psat; D8Ertd814e
Summary
Predicted to enable O-phospho-L-serine:2-oxoglutarate aminotransferase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Predicted to be involved in L-serine biosynthetic process. Predicted to act upstream of or within cellular amino acid biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 2 and PSAT deficiency. Orthologous to human PSAT1 (phosphoserine aminotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 91.8), placenta adult (RPKM 82.6) and 16 other tissues See more
Orthologs
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Genomic context

Location:
19 A; 19 10.86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (15882487..15902423, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (15905123..15925059, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54054 Neighboring gene predicted gene, 46665 Neighboring gene predicted gene, 31733 Neighboring gene predicted gene, 24319 Neighboring gene STARR-seq mESC enhancer starr_45641 Neighboring gene STARR-seq mESC enhancer starr_45643 Neighboring gene STARR-seq mESC enhancer starr_45644 Neighboring gene STARR-seq mESC enhancer starr_45645 Neighboring gene STARR-positive B cell enhancer ABC_E11025 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:15999466-15999649 Neighboring gene RIKEN cDNA C130060C02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4269 Neighboring gene centrosomal protein 78

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables O-phospho-L-serine:2-oxoglutarate aminotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-serine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-serine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphoserine aminotransferase
Names
endometrial progesterone-induced protein
phosphohydroxythreonine aminotransferase
NP_001192268.1
NP_803155.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205339.1NP_001192268.1  phosphoserine aminotransferase isoform 2

    See identical proteins and their annotated locations for NP_001192268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC136453, AK152313
    Consensus CDS
    CCDS57139.1
    UniProtKB/TrEMBL
    Q3U6K9, Q3ULZ3, Q8BTJ1
    Related
    ENSMUSP00000125340.2, ENSMUST00000162053.8
    Conserved Domains (2) summary
    cd00611
    Location:18363
    PSAT_like; Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as ...
    COG1932
    Location:18365
    SerC; Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]
  2. NM_177420.2NP_803155.1  phosphoserine aminotransferase isoform 1

    See identical proteins and their annotated locations for NP_803155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK032487, AK167044, AV166058
    Consensus CDS
    CCDS29681.1
    UniProtKB/Swiss-Prot
    Q99K85
    UniProtKB/TrEMBL
    Q3ULZ3, Q543K5, Q8BTJ1
    Related
    ENSMUSP00000025542.4, ENSMUST00000025542.10
    Conserved Domains (2) summary
    cd00611
    Location:8366
    PSAT_like; Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as ...
    COG1932
    Location:6368
    SerC; Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    15882487..15902423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940109.1 RNA Sequence