U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OGA O-GlcNAcase [ Homo sapiens (human) ]

Gene ID: 10724, updated on 27-Nov-2024

Summary

Official Symbol
OGAprovided by HGNC
Official Full Name
O-GlcNAcaseprovided by HGNC
Primary source
HGNC:HGNC:7056
See related
Ensembl:ENSG00000198408 MIM:604039; AllianceGenome:HGNC:7056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEA5; MGEA5; NCOAT
Summary
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 42.8), lymph node (RPKM 37.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See OGA in Genome Data Viewer
Location:
10q24.32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101784450..101818444, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102667945..102701933, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103544207..103578201, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103529890-103530667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534038-103534776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534777-103535515 Neighboring gene FGF8 5' regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103542131-103542770 Neighboring gene fibroblast growth factor 8 Neighboring gene nucleophosmin/nucleoplasmin 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103577734-103578309 Neighboring gene Sharpr-MPRA regulatory region 4495 Neighboring gene KCNIP2 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103587343-103588542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103590597-103591113 Neighboring gene Sharpr-MPRA regulatory region 3638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103596213-103596713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103603069-103603574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2734 Neighboring gene potassium voltage-gated channel interacting protein 2 Neighboring gene uncharacterized LOC101927445 Neighboring gene armadillo like helical domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ11229, FLJ23355, KIAA0679

General protein information

Preferred Names
protein O-GlcNAcase
Names
N-acetyl-beta-D-glucosaminidase
N-acetyl-beta-glucosaminidase
beta-N-acetylglucosaminidase
beta-N-acetylhexosaminidase
beta-hexosaminidase
bifunctional protein NCOAT
hyaluronidase in meningioma
meningioma expressed antigen 5 (hyaluronidase)
meningioma-expressed antigen 5
nuclear cytoplasmic O-GlcNAcase and acetyltransferase
NP_001135906.1
NP_036347.1
XP_047280470.1
XP_047280471.1
XP_047280472.1
XP_047280473.1
XP_047280474.1
XP_054220599.1
XP_054220600.1
XP_054220601.1
XP_054220602.1
XP_054220603.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142434.2NP_001135906.1  protein O-GlcNAcase isoform b

    See identical proteins and their annotated locations for NP_001135906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC010789
    Consensus CDS
    CCDS44471.1
    UniProtKB/Swiss-Prot
    O60502
    Related
    ENSP00000409973.1, ENST00000439817.5
    Conserved Domains (1) summary
    pfam07555
    Location:62338
    NAGidase; beta-N-acetylglucosaminidase
  2. NM_012215.5NP_036347.1  protein O-GlcNAcase isoform a

    See identical proteins and their annotated locations for NP_036347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC010789
    Consensus CDS
    CCDS7520.1
    UniProtKB/Swiss-Prot
    B7WPB9, D3DR79, E9PGF9, O60502, O75166, Q86WV0, Q8IV98, Q9BVA5, Q9HAR0
    Related
    ENSP00000354850.3, ENST00000361464.8
    Conserved Domains (1) summary
    pfam07555
    Location:62338
    NAGidase; beta-N-acetylglucosaminidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    101784450..101818444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424515.1XP_047280471.1  protein O-GlcNAcase isoform X2

  2. XM_047424514.1XP_047280470.1  protein O-GlcNAcase isoform X1

  3. XM_047424516.1XP_047280472.1  protein O-GlcNAcase isoform X3

  4. XM_047424518.1XP_047280474.1  protein O-GlcNAcase isoform X5

    Related
    ENSP00000359112.3, ENST00000370094.7
  5. XM_047424517.1XP_047280473.1  protein O-GlcNAcase isoform X4

RNA

  1. XR_007061939.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    102667945..102701933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364625.1XP_054220600.1  protein O-GlcNAcase isoform X2

  2. XM_054364624.1XP_054220599.1  protein O-GlcNAcase isoform X1

  3. XM_054364626.1XP_054220601.1  protein O-GlcNAcase isoform X3

  4. XM_054364628.1XP_054220603.1  protein O-GlcNAcase isoform X5

  5. XM_054364627.1XP_054220602.1  protein O-GlcNAcase isoform X4

RNA

  1. XR_008488157.1 RNA Sequence