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OGA O-GlcNAcase [ Homo sapiens (human) ]

Gene ID: 10724, updated on 24-Nov-2020

Summary

Official Symbol
OGAprovided by HGNC
Official Full Name
O-GlcNAcaseprovided by HGNC
Primary source
HGNC:HGNC:7056
See related
Ensembl:ENSG00000198408 MIM:604039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEA5; MGEA5; NCOAT
Summary
The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 42.8), lymph node (RPKM 37.2) and 25 other tissues See more
Orthologs

Genomic context

See OGA in Genome Data Viewer
Location:
10q24.32
Exon count:
17
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (101784445..101818709, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103544200..103578930, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FGF8 5' regulatory region Neighboring gene VISTA enhancer hs513 Neighboring gene nucleophosmin/nucleoplasmin 3 Neighboring gene KCNIP2 antisense RNA 1 Neighboring gene uncharacterized LOC107984029 Neighboring gene potassium voltage-gated channel interacting protein 2 Neighboring gene armadillo like helical domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11229, FLJ23355, KIAA0679

Gene Ontology Provided by GOA

Process Evidence Code Pubs
N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glycoprotein catabolic process TAS
Traceable Author Statement
more info
PubMed 
glycoprotein metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein O-linked glycosylation NAS
Non-traceable Author Statement
more info
PubMed 
protein deglycosylation IDA
Inferred from Direct Assay
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein O-GlcNAcase
Names
N-acetyl-beta-D-glucosaminidase
N-acetyl-beta-glucosaminidase
beta-N-acetylglucosaminidase
beta-N-acetylhexosaminidase
beta-hexosaminidase
bifunctional protein NCOAT
hyaluronidase in meningioma
meningioma expressed antigen 5 (hyaluronidase)
meningioma-expressed antigen 5
nuclear cytoplasmic O-GlcNAcase and acetyltransferase
NP_001135906.1
NP_036347.1
XP_016871074.1
XP_016871075.1
XP_024303550.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142434.2NP_001135906.1  protein O-GlcNAcase isoform b

    See identical proteins and their annotated locations for NP_001135906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC010789
    Consensus CDS
    CCDS44471.1
    UniProtKB/Swiss-Prot
    O60502
    Related
    ENSP00000409973.1, ENST00000439817.5
    Conserved Domains (1) summary
    pfam07555
    Location:62338
    NAGidase; beta-N-acetylglucosaminidase
  2. NM_012215.5NP_036347.1  protein O-GlcNAcase isoform a

    See identical proteins and their annotated locations for NP_036347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC010789
    Consensus CDS
    CCDS7520.1
    UniProtKB/Swiss-Prot
    O60502
    Related
    ENSP00000354850.3, ENST00000361464.8
    Conserved Domains (1) summary
    pfam07555
    Location:62338
    NAGidase; beta-N-acetylglucosaminidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    101784445..101818709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015585.1XP_016871074.1  protein O-GlcNAcase isoform X1

    Conserved Domains (1) summary
    pfam07555
    Location:1223
    NAGidase; beta-N-acetylglucosaminidase
  2. XM_017015586.1XP_016871075.1  protein O-GlcNAcase isoform X2

    Conserved Domains (1) summary
    pfam07555
    Location:20200
    NAGidase; beta-N-acetylglucosaminidase
  3. XM_024447782.1XP_024303550.1  protein O-GlcNAcase isoform X3

    Related
    ENSP00000359112.3, ENST00000370094.7
    Conserved Domains (1) summary
    pfam07555
    Location:62338
    NAGidase; beta-N-acetylglucosaminidase
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