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SLC12A7 solute carrier family 12 member 7 [ Homo sapiens (human) ]

Gene ID: 10723, updated on 24-May-2020

Summary

Official Symbol
SLC12A7provided by HGNC
Official Full Name
solute carrier family 12 member 7provided by HGNC
Primary source
HGNC:HGNC:10915
See related
Ensembl:ENSG00000113504 MIM:604879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCC4
Expression
Ubiquitous expression in testis (RPKM 14.3), kidney (RPKM 13.8) and 25 other tissues See more
Orthologs

Genomic context

See SLC12A7 in Genome Data Viewer
Location:
5p15.33
Exon count:
32
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (1050384..1155887, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (1050489..1112172, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506688 Neighboring gene NKD inhibitor of WNT signaling pathway 2 Neighboring gene microRNA 4635 Neighboring gene uncharacterized LOC105374612 Neighboring gene uncharacterized LOC107986396 Neighboring gene uncharacterized LOC101928857 Neighboring gene solute carrier family 6 member 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434F076

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ammonium transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ammonium import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transport TAS
Traceable Author Statement
more info
 
potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 12 member 7
Names
K-Cl cotransporter 4
SUCO/SLC12A7 fusion
electroneutral potassium-chloride cotransporter 4
potassium/chloride transporter KCC4
solute carrier family 12 (potassium/chloride transporter), member 7
solute carrier family 12 (potassium/chloride transporters), member 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006598.3NP_006589.2  solute carrier family 12 member 7

    See identical proteins and their annotated locations for NP_006589.2

    Status: VALIDATED

    Source sequence(s)
    AC116351, AF105365, AK024497, BC098390, BU953746, DB451347
    Consensus CDS
    CCDS34129.1
    UniProtKB/Swiss-Prot
    Q9Y666
    Related
    ENSP00000264930.5, ENST00000264930.10
    Conserved Domains (2) summary
    TIGR00930
    Location:451083
    2a30; K-Cl cotransporter
    pfam03522
    Location:7091083
    SLC12; Solute carrier family 12

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    1050384..1155887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513941.2XP_011512243.2  solute carrier family 12 member 7 isoform X2

  2. XM_005248231.3XP_005248288.1  solute carrier family 12 member 7 isoform X1

    Conserved Domains (2) summary
    TIGR00930
    Location:451088
    2a30; K-Cl cotransporter
    pfam03522
    Location:7091088
    SLC12; Solute carrier family 12
  3. XM_017008958.1XP_016864447.1  solute carrier family 12 member 7 isoform X5

    Conserved Domains (2) summary
    TIGR00930
    Location:11020
    2a30; K-Cl cotransporter
    pfam03522
    Location:6411020
    SLC12; Solute carrier family 12
  4. XM_011513939.3XP_011512241.1  solute carrier family 12 member 7 isoform X3

    Conserved Domains (2) summary
    TIGR00930
    Location:421085
    2a30; K-Cl cotransporter
    pfam03522
    Location:7061085
    SLC12; Solute carrier family 12
  5. XM_011513940.2XP_011512242.1  solute carrier family 12 member 7 isoform X4

    Conserved Domains (2) summary
    TIGR00930
    Location:311074
    2a30; K-Cl cotransporter
    pfam03522
    Location:6951074
    SLC12; Solute carrier family 12
  6. XM_017008959.1XP_016864448.1  solute carrier family 12 member 7 isoform X5

    Related
    ENSP00000489285.1, ENST00000634447.1
    Conserved Domains (2) summary
    TIGR00930
    Location:11020
    2a30; K-Cl cotransporter
    pfam03522
    Location:6411020
    SLC12; Solute carrier family 12

RNA

  1. XR_925582.2 RNA Sequence

  2. XR_925580.2 RNA Sequence

  3. XR_925579.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187548.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    68893..129745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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