SLC12A7 solute carrier family 12 member 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC12A7provided by HGNC
Official Full Name: solute carrier family 12 member 7provided by HGNC
Primary source: HGNC:HGNC:10915
See related: Ensembl:ENSG00000113504 MIM:604879; AllianceGenome:HGNC:10915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KCC4
Summary: Enables protein kinase binding activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in testis (RPKM 14.3), kidney (RPKM 13.8) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 5p15.33

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (1050384..1155899, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (955618..1061601, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (1050499..1112178, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.
Title: SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus.
The IGF1 gene was amplified in 9 of 19 ACC samples, similar to findings in The Cancer Genome Atlas database. The IGF1 overexpression was observed in 5 samples and was associated with SLC12A7 overexpression and non-functional, early-stage tumors (p < 0.05). endogenous overexpression and silencing of SLC12A7 significantly altered IGF1 and IGF1R expression without impacting other IGFs.
Title: Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinoma.
SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior
Title: SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior.
SLC12A7 gene amplification and overexpression occurs frequently in adrenocortical carcinoma and may play a role in adrenocortical carcinoma tumorigenesis.
Title: DNA copy amplification and overexpression of SLC12A7 in adrenocortical carcinoma.
The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1/2 and NCC were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.
Title: Similar effects of all WNK3 variants on SLC12 cotransporters.
KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 that could result in modulation of KCC activity
Title: K-Cl cotransporter gene expression during human and murine erythroid differentiation.
Negative stain transmission electron microscopy and single particle analysis of KCC4 and the aquaporin-1 AQP1 water channel, revealed the expected quaternary structures within homogeneous preparations, and thus correct protein folding and assembly.
Title: Frog oocytes to unveil the structure and supramolecular organization of human transport proteins.
Observational study of gene-disease association. (HuGE Navigator)
Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.
analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4
Title: Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4.
In the metastatic cancer tissues, KCC4 colocalizes with IGF-I or EGF.
Title: Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of hematological and biochemical traits in a Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chloride:monoatomic cation symporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium:chloride symporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:chloride symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium:chloride symporter activity	TAS Traceable Author Statement more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info
enables symporter activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	TAS Traceable Author Statement more info
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 12 member 7

Names: K-Cl cotransporter 4; SUCO/SLC12A7 fusion; electroneutral potassium-chloride cotransporter 4; potassium/chloride transporter KCC4; solute carrier family 12 (potassium/chloride transporter), member 7; solute carrier family 12 (potassium/chloride transporters), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006598.3 → NP_006589.2 solute carrier family 12 member 7

See identical proteins and their annotated locations for NP_006589.2

Status: VALIDATED

Source sequence(s)

AC116351, AF105365, AK024497, BC098390, BU953746, DB451347

Consensus CDS

CCDS34129.1

UniProtKB/Swiss-Prot

A6NDS8, Q4G0F3, Q96I81, Q9H7I3, Q9H7I7, Q9UFW2, Q9Y666

UniProtKB/TrEMBL

A0A0G2JNW7

Related

ENSP00000264930.5, ENST00000264930.10

Conserved Domains (2) summary

TIGR00930
Location:45 → 1083

2a30; K-Cl cotransporter

pfam03522
Location:709 → 1083

SLC12; Solute carrier family 12

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

1050384..1155899 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011513941.3 → XP_011512243.2 solute carrier family 12 member 7 isoform X2

UniProtKB/TrEMBL

A0A0G2JNW7

Related

ENSP00000521081.1, ENST00000851006.1
XM_005248231.4 → XP_005248288.1 solute carrier family 12 member 7 isoform X1

UniProtKB/TrEMBL

A0A0G2JNW7

Related

ENSP00000615222.1, ENST00000945163.1

Conserved Domains (2) summary

TIGR00930
Location:45 → 1088

2a30; K-Cl cotransporter

pfam03522
Location:709 → 1088

SLC12; Solute carrier family 12
XM_047416640.1 → XP_047272596.1 solute carrier family 12 member 7 isoform X5

UniProtKB/TrEMBL

A0A0U1RR18

Related

ENSP00000489285.1, ENST00000634447.1
XM_017008958.2 → XP_016864447.1 solute carrier family 12 member 7 isoform X5

UniProtKB/TrEMBL

A0A0U1RR18

Conserved Domains (2) summary

TIGR00930
Location:1 → 1020

2a30; K-Cl cotransporter

pfam03522
Location:641 → 1020

SLC12; Solute carrier family 12
XM_011513939.4 → XP_011512241.1 solute carrier family 12 member 7 isoform X3

UniProtKB/TrEMBL

A0A0G2JNW7

Conserved Domains (2) summary

TIGR00930
Location:42 → 1085

2a30; K-Cl cotransporter

pfam03522
Location:706 → 1085

SLC12; Solute carrier family 12
XM_011513940.3 → XP_011512242.1 solute carrier family 12 member 7 isoform X4

UniProtKB/TrEMBL

A0A0G2JNW7

Conserved Domains (2) summary

TIGR00930
Location:31 → 1074

2a30; K-Cl cotransporter

pfam03522
Location:695 → 1074

SLC12; Solute carrier family 12

RNA

XR_007058571.1 RNA Sequence
XR_007058570.1 RNA Sequence
XR_007058569.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187548.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

68893..173552 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328660.1 → XP_054184635.1 solute carrier family 12 member 7 isoform X2

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054328657.1 → XP_054184632.1 solute carrier family 12 member 7 isoform X1

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054328663.1 → XP_054184638.1 solute carrier family 12 member 7 isoform X5

UniProtKB/TrEMBL

A0A0U1RR18
XM_054328664.1 → XP_054184639.1 solute carrier family 12 member 7 isoform X5

UniProtKB/TrEMBL

A0A0U1RR18
XM_054328659.1 → XP_054184634.1 solute carrier family 12 member 7 isoform X7

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054328661.1 → XP_054184636.1 solute carrier family 12 member 7 isoform X3

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054328662.1 → XP_054184637.1 solute carrier family 12 member 7 isoform X4

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054328658.1 → XP_054184633.1 solute carrier family 12 member 7 isoform X6

UniProtKB/TrEMBL

A0A0G2JNW7

RNA

XR_008485603.1 RNA Sequence
XR_008485602.1 RNA Sequence
XR_008485601.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

955618..1061601 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054351454.1 → XP_054207429.1 solute carrier family 12 member 7 isoform X11

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054351451.1 → XP_054207426.1 solute carrier family 12 member 7 isoform X8

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054351457.1 → XP_054207432.1 solute carrier family 12 member 7 isoform X14

UniProtKB/TrEMBL

A0A0U1RR18
XM_054351453.1 → XP_054207428.1 solute carrier family 12 member 7 isoform X10

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054351455.1 → XP_054207430.1 solute carrier family 12 member 7 isoform X12

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054351456.1 → XP_054207431.1 solute carrier family 12 member 7 isoform X13

UniProtKB/TrEMBL

A0A0G2JNW7
XM_054351452.1 → XP_054207427.1 solute carrier family 12 member 7 isoform X9

UniProtKB/TrEMBL

A0A0G2JNW7