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Ffar4 free fatty acid receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 107221, updated on 23-Mar-2024

Summary

Official Symbol
Ffar4provided by MGI
Official Full Name
free fatty acid receptor 4provided by MGI
Primary source
MGI:MGI:2147577
See related
Ensembl:ENSMUSG00000054200 AllianceGenome:MGI:2147577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ffa4; GT01; Pgr4; Gpr120; Gpr129; O3far1; KPG_013
Summary
Enables G protein-coupled receptor activity; fatty acid binding activity; and taste receptor activity. Involved in several processes, including brown fat cell differentiation; positive regulation of cell communication; and positive regulation of cell differentiation. Acts upstream of or within G protein-coupled receptor signaling pathway and hormone secretion. Located in cilium; endocytic vesicle; and plasma membrane. Is expressed in brown fat; intestine; and liver. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FFAR4 (free fatty acid receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 48.3), mammary gland adult (RPKM 17.9) and 10 other tissues See more
Orthologs
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Genomic context

See Ffar4 in Genome Data Viewer
Location:
19 C2; 19 32.73 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38085527..38102711)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38097079..38114263)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene myoferlin Neighboring gene STARR-positive B cell enhancer mm9_chr19:38100719-38101020 Neighboring gene predicted gene, 52396 Neighboring gene STARR-seq mESC enhancer starr_46072 Neighboring gene STARR-positive B cell enhancer ABC_E971 Neighboring gene STARR-seq mESC enhancer starr_46073 Neighboring gene STARR-seq mESC enhancer starr_46074 Neighboring gene centrosomal protein 55 Neighboring gene predicted gene, 23300 Neighboring gene predicted gene, 32440 Neighboring gene retinol binding protein 4, plasma Neighboring gene phosphodiesterase 6C, cGMP specific, cone, alpha prime

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arrestin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables taste receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ghrelin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of somatostatin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucagon secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
free fatty acid receptor 4
Names
G-protein coupled receptor 120
G-protein-coupled receptor GT01
omega-3 fatty acid receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181748.2NP_861413.1  free fatty acid receptor 4

    See identical proteins and their annotated locations for NP_861413.1

    Status: VALIDATED

    Source sequence(s)
    AC101774
    Consensus CDS
    CCDS29783.1
    UniProtKB/Swiss-Prot
    Q7TMA4
    UniProtKB/TrEMBL
    Q3V2S5
    Related
    ENSMUSP00000063660.7, ENSMUST00000067098.8
    Conserved Domains (1) summary
    pfam00001
    Location:77321
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    38085527..38102711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)