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PYDC5 pyrin domain containing 5 [ Homo sapiens (human) ]

Gene ID: 107181291, updated on 31-Oct-2022

Summary

Official Symbol
PYDC5provided by HGNC
Official Full Name
pyrin domain containing 5provided by HGNC
Primary source
HGNC:HGNC:53781
See related
Ensembl:ENSG00000289721 AllianceGenome:HGNC:53781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POP3
Summary
Predicted to enable double-stranded DNA binding activity. Involved in cellular response to interferon-beta; cellular response to virus; and negative regulation of protein-containing complex assembly. Predicted to be part of AIM2 inflammasome complex. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See PYDC5 in Genome Data Viewer
Location:
1q23.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (158999971..159002751, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (158137039..158139819, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158969761..158972541, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pyrin and HIN domain family member 5, pseudogene Neighboring gene pyrin and HIN domain family member 1 Neighboring gene uncharacterized LOC124904432 Neighboring gene interferon gamma inducible protein 16 Neighboring gene absent in melanoma 2 Neighboring gene RAD1 pseudogene 2

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of AIM2 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pyrin domain-containing protein 5
Names
pyrin domain-only protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320010.2NP_001306939.1  pyrin domain-containing protein 5

    Status: VALIDATED

    Source sequence(s)
    AL359753
    Consensus CDS
    CCDS91078.1
    UniProtKB/Swiss-Prot
    W6CW81
    UniProtKB/TrEMBL
    W6CW81
    Related
    ENSP00000513023.1, ENST00000696987.1
    Conserved Domains (1) summary
    cl14633
    Location:1079
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    158999971..159002751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    158137039..158139819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)