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LOC107133510 origin of replication at HBB [ Homo sapiens (human) ]

Gene ID: 107133510, updated on 23-Nov-2021

Summary

Gene symbol
LOC107133510
Gene description
origin of replication at HBB
Gene type
biological region
Feature type(s)
regulatory: DNase_I_hypersensitive_site, matrix_attachment_region, replication_regulatory_region
rep_origin
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region spans the HBB (hemoglobin subunit beta) gene and contains multiple sequences that can function as origins of DNA replication, both endogenously and in ectopic contexts. These origins replicate late in many cell types but early in cells that express hemoglobin, indicating that replication initiation in this region may depend on activity of the globin LCR (locus control region). Indeed, 3C chromatin capture analysis detected an interaction between this region and the HS2 element in the LCR (PMID:21690294), and both replication and transcription factors associate in a single multiprotein complex. Replication may also depend on association of this region with the nuclear matrix, as two scaffold/matrix attachment regions (S/MARs) are also found here. In addition, a DNase I hypersensitive site coincides with a core sequence important for origin activity. [provided by RefSeq, Jan 2016]
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Genomic context

See LOC107133510 in Genome Data Viewer
Location:
11p15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (5222166..5229620)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5243396..5250850)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 51 subfamily V member 1 Neighboring gene beta-globin 3' hypersensitive site 1 Neighboring gene beta-globin gene 3' regulatory region Neighboring gene HBB recombination region Neighboring gene hemoglobin subunit beta Neighboring gene HBD recombination region Neighboring gene delta-globin 5' regulatory region Neighboring gene hemoglobin subunit delta

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046672.1 

    Range
    101..7555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    5222166..5229620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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