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MTCO2P12 MT-CO2 pseudogene 12 [ Homo sapiens (human) ]

Gene ID: 107075310, updated on 8-Mar-2025

Summary

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Official Symbol
MTCO2P12provided by HGNC
Official Full Name
MT-CO2 pseudogene 12provided by HGNC
Primary source
HGNC:HGNC:52028
See related
Ensembl:ENSG00000229344 AllianceGenome:HGNC:52028
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COII; COX2; COXII; MTCO2; MT-CO2
Summary
Contributes to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrial inner membrane. Part of mitochondrial membrane and respiratory chain complex IV. [provided by Alliance of Genome Resources, Mar 2025]
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Genomic context

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See MTCO2P12 in Genome Data Viewer
Location:
1p36.33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (632757..633438)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (568137..568818)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:564533-565276 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:565277-566020 Neighboring gene MT-ND2 pseudogene 28 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:566191-566791 Neighboring gene MT-CO1 pseudogene 12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:567218-567827 Neighboring gene microRNA 12136 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:569139-570114 Neighboring gene MT-ATP8 pseudogene 1 Neighboring gene MT-ATP6 pseudogene 1 Neighboring gene MT-CO3 pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The putative mRNA for subunit II of human cytochrome c oxidase starts directly at the translation initiator codon. Ojala DK, et al. Nature, 1980 Sep 4. PMID 6251383
  2. Nucleotide sequence of human mitochondrial cytochrome c oxidase II cDNA. Power MD, et al. Nucleic Acids Res, 1989 Aug 25. PMID 2550900, Free PMC Article
  3. A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy. Rahman S, et al. Am J Hum Genet, 1999 Oct. PMID 10486321, Free PMC Article
  4. Isoforms of human cytochrome-c oxidase. Subunit composition and steady-state kinetic properties. Van Kuilenburg AB, et al. Eur J Biochem, 1991 Aug 1. PMID 1651240
  5. Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1). Wolff NA, et al. FASEB J, 2014 May. PMID 24448823

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • Cytochrome c oxidase polypeptide II
  • Cytochrome c oxidase subunit 2
  • cytochrome C oxidase II subunit
  • cytochrome c oxidase subunit II
  • mitochondrially encoded cytochrome c oxidase II pseudogene 12
  • sarcoma antigen NY-SAR-71

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to cytochrome-c oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cytochrome-c oxidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lactation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial electron transport, cytochrome c to oxygen NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane HDA PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IDA
Inferred from Direct Assay
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046448.1 

    Range
    101..782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    632757..633438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00403.1 GenPept UniProtKB/Swiss-Prot:P00403

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.