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Wdr74 WD repeat domain 74 [ Mus musculus (house mouse) ]

Gene ID: 107071, updated on 26-Sep-2022

Summary

Official Symbol
Wdr74provided by MGI
Official Full Name
WD repeat domain 74provided by MGI
Primary source
MGI:MGI:2147427
See related
Ensembl:ENSMUSG00000042729 AllianceGenome:MGI:2147427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730436H21Rik
Summary
Acts upstream of or within RNA metabolic process and blastocyst formation. Located in nucleus. Is expressed in 8-cell stage embryo; blastocyst; compacted morula; early conceptus; and secondary oocyte. Orthologous to human WDR74 (WD repeat domain 74). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 17.4), liver E14.5 (RPKM 16.6) and 28 other tissues See more
Orthologs
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Genomic context

See Wdr74 in Genome Data Viewer
Location:
19; 19 A
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8713159..8717988)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8735795..8740624)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 1 Neighboring gene predicted gene, 23246 Neighboring gene small nucleolar RNA, C/D box 22 Neighboring gene testis expressed 54 Neighboring gene syntaxin 5A Neighboring gene microRNA 6992

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of nuclear exosome (RNase complex) ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134139.1NP_598900.1  WD repeat-containing protein 74

    See identical proteins and their annotated locations for NP_598900.1

    Status: VALIDATED

    Source sequence(s)
    BC019968
    Consensus CDS
    CCDS29541.1
    UniProtKB/Swiss-Prot
    Q8VCG3
    Related
    ENSMUSP00000043315.10, ENSMUST00000049424.11
    Conserved Domains (3) summary
    COG2319
    Location:42295
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:91127
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:45302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8713159..8717988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526554.4XP_006526617.1  WD repeat-containing protein 74 isoform X1

    See identical proteins and their annotated locations for XP_006526617.1

    UniProtKB/TrEMBL
    Q8R3V4
    Conserved Domains (2) summary
    sd00039
    Location:5690
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:7167
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...