U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CRK CRK proto-oncogene, adaptor protein [ Gallus gallus (chicken) ]

Gene ID: 107054794, updated on 5-Sep-2025
Symbol
CRKprovided by CGNC
Full Name
CRK proto-oncogene, adaptor proteinprovided by CGNC
Primary source
CGNC:50549
See related
Ensembl:ENSGALG00010029327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
p38; P38C-CRK
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See CRK in Genome Data Viewer
Location:
chromosome: 19
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 19 NC_052550.1 (5650621..5666355)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 19 NC_052591.1 (5387040..5402765)

Chromosome 19 - NC_052550.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417314 Neighboring gene nuclear cap binding subunit 3 Neighboring gene uncharacterized LOC124417313 Neighboring gene uncharacterized LOC121107265 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene myosin IC Neighboring gene uncharacterized LOC121107266 Neighboring gene inositol polyphosphate-5-phosphatase K

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The product of the cellular crk gene consists primarily of SH2 and SH3 regions. Reichman CT, et al. Cell Growth Differ, 1992 Jul. PMID 1329926
  2. Phosphorylation and prolyl isomerization independently regulate the signal adapter function of CrkII. Schmidpeter PAM, et al. J Mol Biol, 2014 Dec 12. PMID 25284755
  3. Molecular determinants of a regulatory prolyl isomerization in the signal adapter protein c-CrkII. Schmidpeter PA, et al. ACS Chem Biol, 2014 May 16. PMID 24571054
  4. Dual role of Cbl links critical events in BCR endocytosis. Jacob M, et al. Int Immunol, 2008 Apr. PMID 18283045
  5. Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells. Tosello-Trampont AC, et al. Cell Death Differ, 2007 May. PMID 17304244

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study analyzed the kinetics of folding and substrate binding of the two homologues and found that cis-trans isomerization of Pro238 determines target binding in chicken but not in human CT10 regulator of kinase protein (c-CrkII).
    Title: Molecular determinants of a regulatory prolyl isomerization in the signal adapter protein c-CrkII.
  2. These data suggest that Dock180/ELMO and CrkII act as two evolutionarily conserved signaling submodules that coordinately regulate engulfment.
    Title: Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells.
  3. Data indicate that human proto-oncogene c-CrkII (CrkII) is regulated by phosphorylation only, but chicken CrkII is regulated by Pro238 trans-->cis isomerization and by Tyr222 phosphorylation.
    Title: Phosphorylation and prolyl isomerization independently regulate the signal adapter function of CrkII.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
adapter molecule crk
Names
proto-oncogene C-crk
v-crk avian sarcoma virus CT10 oncogene homolog
v-crk sarcoma virus CT10 oncogene homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353939.2 → NP_001340868.1  adapter molecule crk

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000323
    UniProtKB/Swiss-Prot
    Q04929
    Related
    ENSGALP00010043617.1, ENSGALT00010070926.1
    Conserved Domains (3) summary
    cd09926
    Location:5 → 123
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:136 → 190
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    cd11759
    Location:238 → 294
    SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    5650621..5666355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015296032.4 → XP_015151518.1  adapter molecule crk isoform X1

    Conserved Domains (2) summary
    cd09926
    Location:5 → 123
    SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
    cd11758
    Location:136 → 190
    SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052591.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    5387040..5402765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046929867.1 → XP_046785823.1  adapter molecule crk isoform X1

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.