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Fbxo38 F-box protein 38 [ Mus musculus (house mouse) ]

Gene ID: 107035, updated on 8-Nov-2022

Summary

Official Symbol
Fbxo38provided by MGI
Official Full Name
F-box protein 38provided by MGI
Primary source
MGI:MGI:2444639
See related
Ensembl:ENSMUSG00000042211 AllianceGenome:MGI:2444639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Moka; SP329; 6030410I24Rik
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T cell mediated immune response to tumor cell; and protein K48-linked ubiquitination. Predicted to act upstream of or within positive regulation of neuron projection development. Located in cytoplasm and nucleus. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 2D. Orthologous to human FBXO38 (F-box protein 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.6), testis adult (RPKM 4.9) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxo38 in Genome Data Viewer
Location:
18; 18 E1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62637130..62681934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62504059..62548863, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene 5 hydroxytryptamine (serotonin) receptor 4 Neighboring gene predicted gene, 36316 Neighboring gene X-linked lymphocyte-regulated 5C pseudogene Neighboring gene serine peptidase inhibitor, Kazal type 10 Neighboring gene serine peptidase inhibitor, Kazal type 7 (putative) Neighboring gene serine peptidase inhibitor, Kazal type 13 Neighboring gene predicted gene, 41751

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
F-box only protein 38
Names
F-box protein modulating KLF7 activity
modulator of KLF7 activity

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361088.1NP_001348017.1  F-box only protein 38 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083
    Conserved Domains (1) summary
    pfam00646
    Location:3065
    F-box; F-box domain
  2. NM_001361089.1NP_001348018.1  F-box only protein 38 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083
  3. NM_001361090.1NP_001348019.1  F-box only protein 38 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083
    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  4. NM_001361091.1NP_001348020.1  F-box only protein 38 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083
  5. NM_134136.4NP_598897.2  F-box only protein 38 isoform 4

    See identical proteins and their annotated locations for NP_598897.2

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083
    Consensus CDS
    CCDS37841.1
    UniProtKB/Swiss-Prot
    Q8BMI0, Q8C0H4
    Related
    ENSMUSP00000047541.7, ENSMUST00000048688.8
    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    62637130..62681934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160927.1XP_036016820.1  F-box only protein 38 isoform X2

    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  2. XM_036160924.1XP_036016817.1  F-box only protein 38 isoform X1

    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  3. XM_036160926.1XP_036016819.1  F-box only protein 38 isoform X2

    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  4. XM_006525501.5XP_006525564.1  F-box only protein 38 isoform X5

    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  5. XM_036160929.1XP_036016822.1  F-box only protein 38 isoform X4

    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  6. XM_036160923.1XP_036016816.1  F-box only protein 38 isoform X1

    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  7. XM_030250266.2XP_030106126.1  F-box only protein 38 isoform X9

  8. XM_036160932.1XP_036016825.1  F-box only protein 38 isoform X7

  9. XM_030250265.2XP_030106125.1  F-box only protein 38 isoform X8

  10. XM_036160930.1XP_036016823.1  F-box only protein 38 isoform X6

  11. XM_036160925.1XP_036016818.1  F-box only protein 38 isoform X1

    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  12. XM_036160928.1XP_036016821.1  F-box only protein 38 isoform X2

    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  13. XM_030250263.2XP_030106123.1  F-box only protein 38 isoform X3

    UniProtKB/Swiss-Prot
    Q8C0H4
    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain
  14. XM_030250264.2XP_030106124.1  F-box only protein 38 isoform X3

    UniProtKB/Swiss-Prot
    Q8C0H4
    Conserved Domains (1) summary
    pfam00646
    Location:3265
    F-box; F-box domain