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Fbxo38 F-box protein 38 [ Mus musculus (house mouse) ]

Gene ID: 107035, updated on 24-Sep-2025
Official Symbol
Fbxo38provided by MGI
Official Full Name
F-box protein 38provided by MGI
Primary source
MGI:MGI:2444639
See related
Ensembl:ENSMUSG00000042211 AllianceGenome:MGI:2444639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Moka; SP329; 6030410I24Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T cell mediated immune response to tumor cell; and protein K48-linked ubiquitination. Predicted to act upstream of or within positive regulation of neuron projection development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; limb bud; retina; spleen; and testis. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 6. Orthologous to human FBXO38 (F-box protein 38). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.6), testis adult (RPKM 4.9) and 28 other tissues See more
Orthologs
human all
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See Fbxo38 in Genome Data Viewer
Location:
18 E1; 18 35.11 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62637130..62681934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62504059..62548863, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene 5 hydroxytryptamine (serotonin) receptor 4 Neighboring gene predicted gene, 36316 Neighboring gene X-linked lymphocyte-regulated 5C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E967 Neighboring gene serine peptidase inhibitor, Kazal type 10 Neighboring gene STARR-seq mESC enhancer starr_44774 Neighboring gene serine peptidase inhibitor, Kazal type 7 (putative) Neighboring gene STARR-seq mESC enhancer starr_44775 Neighboring gene serine peptidase inhibitor, Kazal type 13 Neighboring gene STARR-seq mESC enhancer starr_44776 Neighboring gene predicted gene, 41751

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation. Dibus N, et al. Front Cell Dev Biol, 2022. PMID 35769260, Free PMC Article
  2. FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation. Tian T, et al. Cell Rep, 2023 Nov 28. PMID 37938970
  3. FBXO38 is dispensable for PD-1 regulation. Dibus N, et al. EMBO Rep, 2024 Oct. PMID 39266770, Free PMC Article
  4. Multiple pathways regulate intracellular shuttling of MoKA, a co-activator of transcription factor KLF7. Smaldone S, et al. Nucleic Acids Res, 2006. PMID 16990251, Free PMC Article
  5. A dominant mutation in FBXO38 causes distal spinal muscular atrophy with calf predominance. Sumner CJ, et al. Am J Hum Genet, 2013 Nov 7. PMID 24207122, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBXO38 is dispensable for PD-1 regulation.
    Title: FBXO38 is dispensable for PD-1 regulation.
  2. FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.
    Title: FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.
  3. data indicate that FBXO38 regulates PD-1 expression and highlight an alternative method to block the PD-1 pathway
    Title: FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
  4. MoKA and KLF7 interact functionally to regulate gene expression during cell differentiation
    Title: Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activity.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of T cell mediated immune response to tumor cell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of T cell mediated immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell mediated immune response to tumor cell IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell mediated immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell mediated immune response to tumor cell ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
F-box only protein 38
Names
F-box protein modulating KLF7 activity
modulator of KLF7 activity

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361088.1 → NP_001348017.1  F-box only protein 38 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083
    Conserved Domains (1) summary
    pfam00646
    Location:30 → 65
    F-box; F-box domain

  2. NM_001361089.1 → NP_001348018.1  F-box only protein 38 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083

  3. NM_001361090.1 → NP_001348019.1  F-box only protein 38 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083
    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  4. NM_001361091.1 → NP_001348020.1  F-box only protein 38 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083

  5. NM_134136.4 → NP_598897.2  F-box only protein 38 isoform 4

    See identical proteins and their annotated locations for NP_598897.2

    Status: VALIDATED

    Source sequence(s)
    AC131714, AC165083
    Consensus CDS
    CCDS37841.1
    UniProtKB/Swiss-Prot
    Q8BMI0, Q8BTQ4, Q8C0H4
    Related
    ENSMUSP00000047541.7, ENSMUST00000048688.8
    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    62637130..62681934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160927.1 → XP_036016820.1  F-box only protein 38 isoform X2

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  2. XM_036160924.1 → XP_036016817.1  F-box only protein 38 isoform X1

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  3. XM_036160926.1 → XP_036016819.1  F-box only protein 38 isoform X2

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  4. XM_006525501.5 → XP_006525564.1  F-box only protein 38 isoform X5

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  5. XM_036160929.1 → XP_036016822.1  F-box only protein 38 isoform X4

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  6. XM_036160923.1 → XP_036016816.1  F-box only protein 38 isoform X1

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  7. XM_030250266.2 → XP_030106126.1  F-box only protein 38 isoform X9

  8. XM_036160932.1 → XP_036016825.1  F-box only protein 38 isoform X7

  9. XM_030250265.2 → XP_030106125.1  F-box only protein 38 isoform X8

  10. XM_036160930.1 → XP_036016823.1  F-box only protein 38 isoform X6

  11. XM_036160925.1 → XP_036016818.1  F-box only protein 38 isoform X1

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  12. XM_036160928.1 → XP_036016821.1  F-box only protein 38 isoform X2

    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  13. XM_030250263.2 → XP_030106123.1  F-box only protein 38 isoform X3

    UniProtKB/Swiss-Prot
    Q8BMI0, Q8BTQ4, Q8C0H4
    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain

  14. XM_030250264.2 → XP_030106124.1  F-box only protein 38 isoform X3

    UniProtKB/Swiss-Prot
    Q8BMI0, Q8BTQ4, Q8C0H4
    Conserved Domains (1) summary
    pfam00646
    Location:32 → 65
    F-box; F-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMI0.1 GenPept UniProtKB/Swiss-Prot:Q8BMI0

Gene LinkOut

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