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CETN3 centrin 3 [ Homo sapiens (human) ]

Gene ID: 1070, updated on 8-Jul-2021

Summary

Official Symbol
CETN3provided by HGNC
Official Full Name
centrin 3provided by HGNC
Primary source
HGNC:HGNC:1868
See related
Ensembl:ENSG00000153140 MIM:602907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEN3; CDC31
Summary
The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Broad expression in testis (RPKM 62.8), adrenal (RPKM 10.5) and 21 other tissues See more
Orthologs
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Genomic context

See CETN3 in Genome Data Viewer
Location:
5q14.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (90392257..90409756, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (89688074..89705573, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6868 Neighboring gene long intergenic non-protein coding RNA 1339 Neighboring gene uncharacterized LOC731157 Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene RNA polymerase III subunit G

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Studies using a combined approach of immunofluorescence detection of Gag protein and in situ hybridization detection of viral genomic RNA indicate Gag co-localizes with Psi+ RNA in the perinuclear region and also co-localizes with centrins PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12502, MGC138245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in photoreceptor connecting cilium IEA
Inferred from Electronic Annotation
more info
 
part_of transcription export complex 2 IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centrin-3
Names
CDC31 yeast homolog
EF-hand superfamily member
centrin, EF-hand protein, 3 (CDC31 homolog, yeast)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297765.2NP_001284694.1  centrin-3 isoform 1

    See identical proteins and their annotated locations for NP_001284694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC093510, BM553126, BQ000279, CB998764
    Consensus CDS
    CCDS75274.1
    UniProtKB/TrEMBL
    E5RJF8
    Related
    ENSP00000428259.1, ENST00000522083.5
    Conserved Domains (1) summary
    PTZ00183
    Location:15190
    PTZ00183; centrin; Provisional
  2. NM_001297768.2NP_001284697.1  centrin-3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 3' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC093510, BC093793, BQ000279, BU569574, CB998764
    Consensus CDS
    CCDS78036.1
    UniProtKB/Swiss-Prot
    O15182
    UniProtKB/TrEMBL
    E5RFM2
    Related
    ENSP00000430361.1, ENST00000522864.5
    Conserved Domains (1) summary
    PTZ00183
    Location:15115
    PTZ00183; centrin; Provisional
  3. NM_004365.4NP_004356.2  centrin-3 isoform 2

    See identical proteins and their annotated locations for NP_004356.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC093510, BC005383, BQ000279, CB998764
    Consensus CDS
    CCDS4066.1
    UniProtKB/Swiss-Prot
    O15182
    Related
    ENSP00000283122.3, ENST00000283122.8
    Conserved Domains (1) summary
    PTZ00183
    Location:15166
    PTZ00183; centrin; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    90392257..90409756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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