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ADCY1 adenylate cyclase 1 [ Homo sapiens (human) ]

Gene ID: 107, updated on 11-Jun-2021

Summary

Official Symbol
ADCY1provided by HGNC
Official Full Name
adenylate cyclase 1provided by HGNC
Primary source
HGNC:HGNC:232
See related
Ensembl:ENSG00000164742 MIM:103072
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AC1; DFNB44
Summary
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Biased expression in brain (RPKM 14.3), testis (RPKM 1.6) and 7 other tissues See more
Orthologs
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Genomic context

See ADCY1 in Genome Data Viewer
Location:
7p12.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (45574140..45723116)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (45613739..45762715)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ELK1 pseudogene 1 Neighboring gene uncharacterized LOC107986737 Neighboring gene septin 7 pseudogene 2 Neighboring gene general transcription factor IIi pseudogene 13 Neighboring gene RNA, U6 small nuclear 241, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of adenylate cyclase 1 (ADCY1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The addition of HIV-1 gp120 with TNF-alpha to human B-cells stimulates cAMP production in a dose-dependent manner PubMed
Envelope transmembrane glycoprotein gp41 env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
Nef nef HIV-1 induces the upregulation of complement factor C3 in astrocytes and neurons through signaling pathways that involve protein kinase C and adenylate cyclase activation, which is an effect that may contribute to the pathogenesis of AIDS in the brain PubMed
Tat tat The gene expression of adenylate cyclase 1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
tat HIV-1 Tat inhibits adenylyl cyclase activity in microglia and astrocyte cultures from neonatal rat brain, suggesting that Tat inhibition of cAMP synthesis may contribute to neuronal degeneration and cell death associated with HIV infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium- and calmodulin-responsive adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium- and calmodulin-responsive adenylate cyclase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
 
involved_in activation of protein kinase A activity TAS
Traceable Author Statement
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cAMP biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to forskolin ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to glucagon stimulus TAS
Traceable Author Statement
more info
 
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in long-term memory IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of inflammatory response to antigenic stimulus TAS
Traceable Author Statement
more info
 
involved_in neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of CREB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in renal water homeostasis TAS
Traceable Author Statement
more info
 
involved_in response to drug IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
adenylate cyclase type 1
Names
3',5'-cyclic AMP synthetase
ATP pyrophosphate-lyase 1
Ca(2+)/calmodulin-activated adenylyl cyclase
adenyl cyclase
adenylate cyclase 1 (brain)
adenylate cyclase type I
adenylyl cyclase 1
adenylyl cyclase subtype 1
NP_001268697.1
NP_066939.1
XP_005249641.1
XP_005249642.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034198.1 RefSeqGene

    Range
    5229..153977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1172

mRNA and Protein(s)

  1. NM_001281768.2NP_001268697.1  adenylate cyclase type 1 isoform 2

    See identical proteins and their annotated locations for NP_001268697.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' and 3' UTR and has multiple differences in the coding region compared to variant 1. The encoded isoform (2) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC091439, BC041473
    Consensus CDS
    CCDS75593.1
    UniProtKB/TrEMBL
    C9J1J0
    Related
    ENSP00000392721.1, ENST00000432715.5
    Conserved Domains (3) summary
    smart00044
    Location:33228
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:69251
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:367
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  2. NM_021116.4NP_066939.1  adenylate cyclase type 1 isoform 1

    See identical proteins and their annotated locations for NP_066939.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB209496, AC069008, AC091439, AF497515
    Consensus CDS
    CCDS34631.1
    UniProtKB/Swiss-Prot
    Q08828
    Related
    ENSP00000297323.7, ENST00000297323.12
    Conserved Domains (3) summary
    smart00044
    Location:258453
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8591056
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:161292
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    45574140..45723116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249584.3XP_005249641.1  adenylate cyclase type 1 isoform X1

    Conserved Domains (4) summary
    smart00044
    Location:258453
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:294476
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:161292
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    cl11967
    Location:859978
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
  2. XM_005249585.2XP_005249642.1  adenylate cyclase type 1 isoform X2

    See identical proteins and their annotated locations for XP_005249642.1

    Conserved Domains (3) summary
    smart00044
    Location:258453
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:294476
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:161292
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
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