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Slc39a6 solute carrier family 39 (metal ion transporter), member 6 [ Mus musculus (house mouse) ]

Gene ID: 106957, updated on 21-Apr-2024

Summary

Official Symbol
Slc39a6provided by MGI
Official Full Name
solute carrier family 39 (metal ion transporter), member 6provided by MGI
Primary source
MGI:MGI:2147279
See related
Ensembl:ENSMUSG00000024270 AllianceGenome:MGI:2147279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zip6; Ermelin
Summary
Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in cellular zinc ion homeostasis and zinc ion import across plasma membrane. Predicted to act upstream of or within zinc ion transport. Located in endoplasmic reticulum. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human SLC39A6 (solute carrier family 39 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 19.9), CNS E14 (RPKM 19.7) and 24 other tissues See more
Orthologs
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Genomic context

Location:
18 A2; 18 13.18 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (24712938..24736874, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (24579881..24603817, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2700062C07 gene Neighboring gene predicted gene, 54038 Neighboring gene regulation of nuclear pre-mRNA domain containing 1A Neighboring gene STARR-positive B cell enhancer ABC_E9972 Neighboring gene STARR-seq mESC enhancer starr_44068 Neighboring gene STARR-seq mESC enhancer starr_44069 Neighboring gene STARR-seq mESC enhancer starr_44070 Neighboring gene STARR-seq mESC enhancer starr_44071 Neighboring gene STARR-positive B cell enhancer ABC_E8706 Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene molybdenum cofactor sulfurase Neighboring gene STARR-positive B cell enhancer mm9_chr18:24835661-24835962

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic cation:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in lymphocyte activation ISO
Inferred from Sequence Orthology
more info
 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within zinc ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc transporter ZIP6
Names
ZIP-6
endoplasmic reticulum membrane protein
endoplasmic reticulum membrane-linked protein
solute carrier family 39 member 6
zrt- and Irt-like protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139143.3NP_631882.2  zinc transporter ZIP6 precursor

    See identical proteins and their annotated locations for NP_631882.2

    Status: VALIDATED

    Source sequence(s)
    AK028976, BC055012, CK619600
    Consensus CDS
    CCDS50239.1
    UniProtKB/Swiss-Prot
    Q7TPP9, Q7TQE0, Q8C145, Q8R518
    Related
    ENSMUSP00000064667.4, ENSMUST00000070726.10
    Conserved Domains (1) summary
    pfam02535
    Location:333752
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    24712938..24736874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)