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CCT8 chaperonin containing TCP1 subunit 8 [ Homo sapiens (human) ]

Gene ID: 10694, updated on 9-Feb-2020

Summary

Official Symbol
CCT8provided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 8provided by HGNC
Primary source
HGNC:HGNC:1623
See related
Ensembl:ENSG00000156261 MIM:617786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cctq; PRED71; D21S246; C21orf112
Summary
This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in adrenal (RPKM 57.9), lymph node (RPKM 57.3) and 25 other tissues See more
Orthologs

Genomic context

See CCT8 in Genome Data Viewer
Location:
21q21.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (29056322..29073797, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (30428647..30446010, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene RWD domain containing 2B Neighboring gene ubiquitin specific peptidase 16 Neighboring gene MAP3K7 C-terminal like Neighboring gene Sharpr-MPRA regulatory region 4059 Neighboring gene ribosomal protein L12 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with CCT8 PubMed
Pr55(Gag) gag Cellular biotinylated CCT8 chaperonin containing TCP1, subunit 8 (theta) protein is incorporated into HIV-1 Gag virus-like particles PubMed
Vif vif HIV-1 Vif interacts with CCT8 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0002

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled TAS
Traceable Author Statement
more info
PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cell body IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
chaperonin-containing T-complex TAS
Traceable Author Statement
more info
PubMed 
cilium IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol HDA PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 
zona pellucida receptor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
T-complex protein 1 subunit theta
Names
CCT-theta
TCP-1-theta
chaperonin containing T-complex polypeptide 1 subunit 8
chaperonin containing TCP1, subunit 8 (theta)
renal carcinoma antigen NY-REN-15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282907.1NP_001269836.1  T-complex protein 1 subunit theta isoform 2

    See identical proteins and their annotated locations for NP_001269836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and contains an alternate exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK293705, BC072001, BP248736, DB301557, DC298601
    Consensus CDS
    CCDS68181.1
    UniProtKB/Swiss-Prot
    P50990
    Related
    ENSP00000486921.1, ENST00000626972.2
    Conserved Domains (1) summary
    TIGR02346
    Location:2520
    chap_CCT_theta; T-complex protein 1, theta subunit
  2. NM_001282908.1NP_001269837.1  T-complex protein 1 subunit theta isoform 3

    See identical proteins and their annotated locations for NP_001269837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC012584, BP248736, DB301557
    UniProtKB/TrEMBL
    Q7Z759
    Conserved Domains (2) summary
    pfam00118
    Location:1477
    Cpn60_TCP1; TCP-1/cpn60 chaperonin family
    cl02777
    Location:1488
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
  3. NM_001282909.1NP_001269838.1  T-complex protein 1 subunit theta isoform 4

    See identical proteins and their annotated locations for NP_001269838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 4, which has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK298801, BC072001, BP248736, DB301557
    Consensus CDS
    CCDS68180.1
    UniProtKB/Swiss-Prot
    P50990
    Related
    ENSP00000442730.1, ENST00000540844.5
    Conserved Domains (1) summary
    cl02777
    Location:5466
    chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
  4. NM_006585.4NP_006576.2  T-complex protein 1 subunit theta isoform 1

    See identical proteins and their annotated locations for NP_006576.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC072001
    Consensus CDS
    CCDS33528.1
    UniProtKB/Swiss-Prot
    P50990
    Related
    ENSP00000286788.4, ENST00000286788.9
    Conserved Domains (1) summary
    TIGR02346
    Location:10539
    chap_CCT_theta; T-complex protein 1, theta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    29056322..29073797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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