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Tnfaip8 tumor necrosis factor, alpha-induced protein 8 [ Mus musculus (house mouse) ]

Gene ID: 106869, updated on 5-Mar-2024

Summary

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Official Symbol
Tnfaip8provided by MGI
Official Full Name
tumor necrosis factor, alpha-induced protein 8provided by MGI
Primary source
MGI:MGI:2147191
See related
Ensembl:ENSMUSG00000062210 AllianceGenome:MGI:2147191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nded; Tipe; Gg2-1; Ssc-2; Gm10539; E130304C20Rik
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Acts upstream of or within defense response to Gram-positive bacterium. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; choroid plexus; musculoskeletal system; respiratory system; and thymus primordium. Orthologous to human TNFAIP8 (TNF alpha induced protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 36.9), placenta adult (RPKM 10.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 D1; 18 27.18 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (50112494..50226296)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (49979427..50093229)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700065O20 gene Neighboring gene STARR-seq mESC enhancer starr_44570 Neighboring gene Dmx-like 1 Neighboring gene STARR-seq mESC enhancer starr_44572 Neighboring gene STARR-positive B cell enhancer ABC_E1957 Neighboring gene STARR-positive B cell enhancer ABC_E7584 Neighboring gene STARR-positive B cell enhancer ABC_E8716 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:50183799-50183908 Neighboring gene STARR-positive B cell enhancer ABC_E4248 Neighboring gene RIKEN cDNA C030005K06 gene Neighboring gene predicted gene, 33335 Neighboring gene STARR-positive B cell enhancer ABC_E5657 Neighboring gene STARR-positive B cell enhancer ABC_E4249 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 4 Neighboring gene CD63 antigen, pseudogene Neighboring gene predicted gene, 33376

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis. Lou Y, et al. Cell Death Dis, 2022 Apr 6. PMID 35387985, Free PMC Article
  2. TNFAIP8 Regulates Intestinal Epithelial Cell Differentiation and May Alter Terminal Differentiation of Secretory Progenitors. Hood R, et al. Cells, 2021 Apr 12. PMID 33921306, Free PMC Article
  3. TNFAIP8 influences the motor function in mice after spinal cord injury (SCI) through meditating inflammation dependent on AKT. Xue W, et al. Biochem Biophys Res Commun, 2020 Jul 12. PMID 32487318
  4. TNFAIP8 Deficiency Exacerbates Acute Graft Versus Host Disease in a Murine Model of Allogeneic Hematopoietic Cell Transplantation. Kumari R, et al. Transplantation, 2020 Mar. PMID 31634333, Free PMC Article
  5. TIPE attenuates the apoptotic effect of radiation and cisplatin and promotes tumor growth via JNK and p38 activation in Raw264.7 and EL4 cells. Liu Y, et al. Oncol Rep, 2018 Jun. PMID 29620232

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis.
    Title: TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis.
  2. Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8.
    Title: Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8.
  3. TNFAIP8 Regulates Intestinal Epithelial Cell Differentiation and May Alter Terminal Differentiation of Secretory Progenitors.
    Title: TNFAIP8 Regulates Intestinal Epithelial Cell Differentiation and May Alter Terminal Differentiation of Secretory Progenitors.
  4. TNFAIP8 influences the motor function in mice after spinal cord injury (SCI) through meditating inflammation dependent on AKT.
    Title: TNFAIP8 influences the motor function in mice after spinal cord injury (SCI) through meditating inflammation dependent on AKT.
  5. The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation.
    Title: The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation.
  6. TNFAIP8 Deficiency Exacerbates Acute Graft Versus Host Disease in a Murine Model of Allogeneic Hematopoietic Cell Transplantation.
    Title: TNFAIP8 Deficiency Exacerbates Acute Graft Versus Host Disease in a Murine Model of Allogeneic Hematopoietic Cell Transplantation.
  7. TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling.
    Title: TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling.
  8. Study revealed that TIPE overexpression obviously augmented the volume and weight of the tumors, indicating that TIPE facilitates tumor formation probably through its antiapoptotic effect on JNK and p38 activation.
    Title: TIPE attenuates the apoptotic effect of radiation and cisplatin and promotes tumor growth via JNK and p38 activation in Raw264.7 and EL4 cells.
  9. TNFAIP8 expression following CLP may be associated with the pathogenesis of immune dysfunction in splenic T lymphocytes in mice.
    Title: Effect of tumor necrosis factor-α-induced protein 8 on the immune response of CD4+ T lymphocytes in mice following acute insult.
  10. CD4+ T lymphocyte proliferative activity was significantly down-regulated when TNFAIP8 gene was silenced by siRNA in mice at 24 h post burn. Down-regulation of TNFAIP8 can significantly decrease expression levels of IL-2 and soluble IL-2R at 24 h after thermal injury.
    Title: Effect of tumor necrosis factor-induced protein 8 on T-cell-mediated immunity in mice after thermal injury.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
enables molecular sequestering activity EXP
Inferred from Experiment
more info
 PubMed 
enables small molecule binding EXP
Inferred from Experiment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor alpha-induced protein 8
Names
TNF alpha-induced protein 8
TNF-induced protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177759.1 → NP_001171230.1  tumor necrosis factor alpha-induced protein 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a distinct translation start site, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC120859, AC166570
    Consensus CDS
    CCDS50288.1
    UniProtKB/Swiss-Prot
    Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
    UniProtKB/TrEMBL
    D3YWJ5
    Related
    ENSMUSP00000120712.3, ENSMUST00000148989.3
    Conserved Domains (1) summary
    pfam05527
    Location:7 → 185
    DUF758; Domain of unknown function (DUF758)

  2. NM_001177760.1 → NP_001171231.1  tumor necrosis factor alpha-induced protein 8 isoform 3

    See identical proteins and their annotated locations for NP_001171231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, and lacks an alternate segment, compared to variant 1. The resulting isoform (3z) has shorter and distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC120859, AK163339, BB623947
    Consensus CDS
    CCDS50287.1
    UniProtKB/Swiss-Prot
    Q921Z5
    Related
    ENSMUSP00000136030.2, ENSMUST00000179937.2
    Conserved Domains (1) summary
    pfam05527
    Location:7 → 109
    DUF758; Domain of unknown function (DUF758)

  3. NM_001360935.1 → NP_001347864.1  tumor necrosis factor alpha-induced protein 8 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR and uses a distinct translation start site, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC120859
    UniProtKB/Swiss-Prot
    Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
    Related
    ENSMUSP00000136152.2, ENSMUST00000128377.2
    Conserved Domains (1) summary
    pfam05527
    Location:11 → 189
    DUF758; Domain of unknown function (DUF758)

  4. NM_134131.2 → NP_598892.2  tumor necrosis factor alpha-induced protein 8 isoform 1

    See identical proteins and their annotated locations for NP_598892.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC120859, AK149901, BY108131
    Consensus CDS
    CCDS37817.2
    UniProtKB/Swiss-Prot
    Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
    UniProtKB/TrEMBL
    D3Z325
    Related
    ENSMUSP00000119041.3, ENSMUST00000148159.3
    Conserved Domains (1) summary
    pfam05527
    Location:51 → 205
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    50112494..50226296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250259.1 → XP_030106119.1  tumor necrosis factor alpha-induced protein 8 isoform X3

    UniProtKB/Swiss-Prot
    Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
    Conserved Domains (1) summary
    pfam05527
    Location:1 → 163
    DUF758; Domain of unknown function (DUF758)

  2. XM_006525480.2 → XP_006525543.1  tumor necrosis factor alpha-induced protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006525543.1

    UniProtKB/Swiss-Prot
    Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
    Conserved Domains (1) summary
    pfam05527
    Location:10 → 188
    DUF758; Domain of unknown function (DUF758)

  3. XM_011246796.2 → XP_011245098.1  tumor necrosis factor alpha-induced protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011245098.1

    UniProtKB/Swiss-Prot
    Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
    UniProtKB/TrEMBL
    D3Z325
    Conserved Domains (1) summary
    pfam05527
    Location:51 → 205
    DUF758; Domain of unknown function (DUF758)

  4. XM_036160917.1 → XP_036016810.1  tumor necrosis factor alpha-induced protein 8 isoform X1

    UniProtKB/Swiss-Prot
    Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
    UniProtKB/TrEMBL
    D3Z325
    Conserved Domains (1) summary
    pfam05527
    Location:51 → 205
    DUF758; Domain of unknown function (DUF758)

  5. XM_030250258.1 → XP_030106118.1  tumor necrosis factor alpha-induced protein 8 isoform X3

    UniProtKB/Swiss-Prot
    Q3TQS5, Q3U9V7, Q3UBG8, Q8BTH4, Q921Z5
    Conserved Domains (1) summary
    pfam05527
    Location:1 → 163
    DUF758; Domain of unknown function (DUF758)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921Z5.1 GenPept UniProtKB/Swiss-Prot:Q921Z5

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