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Abhd3 abhydrolase domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 106861, updated on 8-Dec-2022

Summary

Official Symbol
Abhd3provided by MGI
Official Full Name
abhydrolase domain containing 3provided by MGI
Primary source
MGI:MGI:2147183
See related
Ensembl:ENSMUSG00000002475 AllianceGenome:MGI:2147183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LABH3
Summary
Predicted to enable carboxylic ester hydrolase activity. Involved in phosphatidylcholine metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; genitourinary system; liver; olfactory epithelium; and spleen. Orthologous to human ABHD3 (abhydrolase domain containing 3, phospholipase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 12.2), liver adult (RPKM 11.7) and 20 other tissues See more
Orthologs
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Genomic context

See Abhd3 in Genome Data Viewer
Location:
18; 18 A1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10644411..10706784, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10644411..10706783, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 1 Neighboring gene small nuclear ribonucleoprotein D1 Neighboring gene RIKEN cDNA 4930563E18 gene Neighboring gene MIB E3 ubiquitin protein ligase 1 Neighboring gene predicted gene, 25116

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables acetylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A1 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in medium-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in medium-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylcholine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipase ABHD3
Names
abhydrolase domain-containing protein 3
lung alpha/beta hydrolase 3
mmLABH3
NP_598891.1
XP_011245095.1
XP_011245096.1
XP_036016808.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134130.1NP_598891.1  phospholipase ABHD3

    See identical proteins and their annotated locations for NP_598891.1

    Status: VALIDATED

    Source sequence(s)
    AF429302
    Consensus CDS
    CCDS29057.1
    UniProtKB/Swiss-Prot
    Q3UNF7, Q91ZH7
    UniProtKB/TrEMBL
    A0A8C6HSF3
    Related
    ENSMUSP00000113137.3, ENSMUST00000117828.9
    Conserved Domains (2) summary
    PLN02511
    Location:39403
    PLN02511; hydrolase
    cl21494
    Location:92398
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    10644411..10706784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160915.1XP_036016808.1  phospholipase ABHD3 isoform X1

    Conserved Domains (1) summary
    PLN02511
    Location:18311
    PLN02511; hydrolase
  2. XM_011246793.3XP_011245095.1  phospholipase ABHD3 isoform X2

    Conserved Domains (1) summary
    PLN02511
    Location:39223
    PLN02511; hydrolase
  3. XM_011246794.3XP_011245096.1  phospholipase ABHD3 isoform X3

    Conserved Domains (1) summary
    PLN02511
    Location:39190
    PLN02511; hydrolase

RNA

  1. XR_004939811.1 RNA Sequence

  2. XR_385966.5 RNA Sequence