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CETN1 centrin 1 [ Homo sapiens (human) ]

Gene ID: 1068, updated on 8-Dec-2018

Summary

Official Symbol
CETN1provided by HGNC
Official Full Name
centrin 1provided by HGNC
Primary source
HGNC:HGNC:1866
See related
Ensembl:ENSG00000177143 MIM:603187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEN1; CETN
Summary
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]
Orthologs

Genomic context

See CETN1 in Genome Data Viewer
Location:
18p11.32
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (580343..582020)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (580369..581524)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene collectin subfamily member 12 Neighboring gene uncharacterized LOC107985155 Neighboring gene long intergenic non-protein coding RNA 1925 Neighboring gene RNA, 7SK small nuclear pseudogene 146 Neighboring gene uncharacterized LOC105371952 Neighboring gene clusterin like 1

Genomic regions, transcripts, and products

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Studies using a combined approach of immunofluorescence detection of Gag protein and in situ hybridization detection of viral genomic RNA indicate Gag co-localizes with Psi+ RNA in the perinuclear region and also co-localizes with centrins PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centriole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
photoreceptor connecting cilium IEA
Inferred from Electronic Annotation
more info
 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centrin-1
Names
EF-hand protein
calcium binding protein
caltractin
centrin, EF-hand protein, 1
testicular tissue protein Li 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004066.2NP_004057.1  centrin-1

    See identical proteins and their annotated locations for NP_004057.1

    Status: REVIEWED

    Source sequence(s)
    AI198628, AP001178, BC029515, DB448454
    Consensus CDS
    CCDS11820.1
    UniProtKB/Swiss-Prot
    Q12798
    UniProtKB/TrEMBL
    A0A140VJG3
    Related
    ENSP00000319052.3, ENST00000327228.4
    Conserved Domains (1) summary
    PTZ00183
    Location:22172
    PTZ00183; centrin; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    580343..582020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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