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CETN1 centrin 1 [ Homo sapiens (human) ]

Gene ID: 1068, updated on 11-Jun-2017
Official Symbol
CETN1provided by HGNC
Official Full Name
centrin 1provided by HGNC
Primary source
HGNC:HGNC:1866
See related
Ensembl:ENSG00000177143 MIM:603187; Vega:OTTHUMG00000131471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEN1; CETN
Summary
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]
Orthologs
Location:
18p11.32
Exon count:
1
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 18 NC_000018.10 (580343..582020)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (580369..581524)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene collectin subfamily member 12 Neighboring gene uncharacterized LOC107985155 Neighboring gene long intergenic non-protein coding RNA 1925 Neighboring gene RNA, 7SK small nuclear pseudogene 146 Neighboring gene uncharacterized LOC105371952 Neighboring gene clusterin like 1

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Studies using a combined approach of immunofluorescence detection of Gag protein and in situ hybridization detection of viral genomic RNA indicate Gag co-localizes with Psi+ RNA in the perinuclear region and also co-localizes with centrins PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
heterotrimeric G-protein binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
photoreceptor connecting cilium IEA
Inferred from Electronic Annotation
more info
 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
centrin-1
Names
EF-hand protein
calcium binding protein
caltractin
centrin, EF-hand protein, 1
testicular tissue protein Li 37

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004066.2NP_004057.1  centrin-1

    See identical proteins and their annotated locations for NP_004057.1

    Status: REVIEWED

    Source sequence(s)
    AI198628, AP001178, BC029515, DB448454
    Consensus CDS
    CCDS11820.1
    UniProtKB/Swiss-Prot
    Q12798
    UniProtKB/TrEMBL
    A0A140VJG3
    Related
    ENSP00000319052.3, OTTHUMP00000162193, ENST00000327228.4, OTTHUMT00000254314
    Conserved Domains (2) summary
    PTZ00183
    Location:22172
    PTZ00183; centrin; Provisional
    cd00051
    Location:105167
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p7 Primary Assembly

    Range
    580343..582020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    579772..581449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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