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DCTN6 dynactin subunit 6 [ Homo sapiens (human) ]

Gene ID: 10671, updated on 1-Jun-2020

Summary

Official Symbol
DCTN6provided by HGNC
Official Full Name
dynactin subunit 6provided by HGNC
Primary source
HGNC:HGNC:16964
See related
Ensembl:ENSG00000104671 MIM:612963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WS3; p27; WS-3
Summary
The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 33.5), fat (RPKM 26.8) and 25 other tissues See more
Orthologs

Genomic context

See DCTN6 in Genome Data Viewer
Location:
8p12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30156369..30183639)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30013813..30041155)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene leptin receptor overlapping transcript like 1 Neighboring gene ribosomal protein S15a pseudogene 24 Neighboring gene membrane bound O-acyltransferase domain containing 4 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 11 Neighboring gene transgelin 2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dynactin complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynactin subunit 6
Names
dynactin 6
dynactin subunit p27
novel RGD-containing protein
protein WS-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006571.4NP_006562.1  dynactin subunit 6

    See identical proteins and their annotated locations for NP_006562.1

    Status: REVIEWED

    Source sequence(s)
    BC013175, D79389
    Consensus CDS
    CCDS6076.1
    UniProtKB/Swiss-Prot
    O00399
    Related
    ENSP00000221114.3, ENST00000221114.8
    Conserved Domains (1) summary
    cd04646
    Location:10179
    LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    30156369..30183639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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