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Trip10 thyroid hormone receptor interactor 10 [ Mus musculus (house mouse) ]

Gene ID: 106628, updated on 26-Sep-2022

Summary

Official Symbol
Trip10provided by MGI
Official Full Name
thyroid hormone receptor interactor 10provided by MGI
Primary source
MGI:MGI:2146901
See related
Ensembl:ENSMUSG00000019487 AllianceGenome:MGI:2146901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cip4
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including hyperosmotic salinity response; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of cell growth involved in cardiac muscle cell development. Predicted to be located in nucleoplasm. Is expressed in several structures, including clavicle; cranium; inner ear; submandibular gland primordium; and trigeminal ganglion. Orthologous to human TRIP10 (thyroid hormone receptor interactor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 19.3), heart adult (RPKM 17.6) and 28 other tissues See more
Orthologs
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Genomic context

See Trip10 in Genome Data Viewer
Location:
17; 17 D
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57540227..57570697)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57233220..57263697)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor (ligand) superfamily, member 14 Neighboring gene complement component 3 Neighboring gene microRNA 6978 Neighboring gene G protein-coupled receptor 108 Neighboring gene SH2 domain containing 3A pseudogene Neighboring gene predicted gene, 52326

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in hyperosmotic salinity response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cdc42-interacting protein 4
Names
Cdc42 interacting protein-4
TR-interacting protein 10
TRIP-10
thyroid receptor-interacting protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242389.2NP_001229318.1  cdc42-interacting protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001229318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    CT025692
    Consensus CDS
    CCDS89129.1
    UniProtKB/Swiss-Prot
    Q8CJ53, Q99LI0
    Related
    ENSMUSP00000153081.2, ENSMUST00000224152.2
    Conserved Domains (3) summary
    cd07653
    Location:5257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:395475
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:546600
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
  2. NM_001242390.2NP_001229319.1  cdc42-interacting protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001229319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    CT025692
    Consensus CDS
    CCDS89130.1
    UniProtKB/Swiss-Prot
    Q8CJ53
    Related
    ENSMUSP00000153576.2, ENSMUST00000224885.2
    Conserved Domains (3) summary
    cd07653
    Location:5257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:395475
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:545599
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
  3. NM_001242391.2NP_001229320.1  cdc42-interacting protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001229320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but lacks two alternate internal segments compared to isoform 1.
    Source sequence(s)
    CT025692
    Consensus CDS
    CCDS89131.1
    UniProtKB/Swiss-Prot
    Q8CJ53
    Related
    ENSMUSP00000019631.11, ENSMUST00000019631.11
    Conserved Domains (3) summary
    cd07653
    Location:5257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:339419
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:489543
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
  4. NM_001410293.1NP_001397222.1  cdc42-interacting protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT025692
  5. NM_001410294.1NP_001397223.1  cdc42-interacting protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    CT025692
  6. NM_001410295.1NP_001397224.1  cdc42-interacting protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT025692
  7. NM_001410296.1NP_001397225.1  cdc42-interacting protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    CT025692
  8. NM_001410297.1NP_001397226.1  cdc42-interacting protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    CT025692
  9. NM_001410298.1NP_001397227.1  cdc42-interacting protein 4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    CT025692
  10. NM_001410299.1NP_001397228.1  cdc42-interacting protein 4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    CT025692
  11. NM_001410300.1NP_001397229.1  cdc42-interacting protein 4 isoform 12

    Status: VALIDATED

    Source sequence(s)
    CT025692
  12. NM_001410301.1NP_001397230.1  cdc42-interacting protein 4 isoform 13

    Status: VALIDATED

    Source sequence(s)
    CT025692
  13. NM_001410302.1NP_001397231.1  cdc42-interacting protein 4 isoform 14

    Status: VALIDATED

    Source sequence(s)
    CT025692
  14. NM_001410303.1NP_001397232.1  cdc42-interacting protein 4 isoform 15

    Status: VALIDATED

    Source sequence(s)
    CT025692
  15. NM_134125.5NP_598886.1  cdc42-interacting protein 4 isoform 3

    See identical proteins and their annotated locations for NP_598886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CT025692
    Consensus CDS
    CCDS28930.1
    UniProtKB/Swiss-Prot
    Q8CJ53
    Related
    ENSMUSP00000153467.2, ENSMUST00000224947.2
    Conserved Domains (3) summary
    cd07653
    Location:5257
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:339419
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:490544
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57540227..57570697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523401.5XP_006523464.1  cdc42-interacting protein 4 isoform X2

    Conserved Domains (3) summary
    cd11628
    Location:360440
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:511565
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
    cl12013
    Location:31222
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_006523400.4XP_006523463.1  cdc42-interacting protein 4 isoform X1

    Conserved Domains (3) summary
    cd07653
    Location:5238
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:376456
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:527581
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
  3. XM_036160247.1XP_036016140.1  cdc42-interacting protein 4 isoform X3

    Conserved Domains (3) summary
    cd07653
    Location:5238
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:320400
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:471525
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
  4. XM_036160248.1XP_036016141.1  cdc42-interacting protein 4 isoform X4

    Conserved Domains (3) summary
    cd07653
    Location:5238
    F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
    cd11628
    Location:320400
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd11911
    Location:470524
    SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4