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KHDRBS3 KH RNA binding domain containing, signal transduction associated 3 [ Homo sapiens (human) ]

Gene ID: 10656, updated on 1-Aug-2020

Summary

Official Symbol
KHDRBS3provided by HGNC
Official Full Name
KH RNA binding domain containing, signal transduction associated 3provided by HGNC
Primary source
HGNC:HGNC:18117
See related
Ensembl:ENSG00000131773 MIM:610421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Etle; SALP; SLM2; SLM-2; TSTAR; T-STAR; etoile
Expression
Biased expression in testis (RPKM 33.1), brain (RPKM 14.0) and 10 other tissues See more
Orthologs

Genomic context

See KHDRBS3 in Genome Data Viewer
Location:
8q24.23
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (135457456..135656516)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (136469702..136669068)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a pseudogene 56 Neighboring gene long intergenic non-protein coding RNA 1591 Neighboring gene uncharacterized LOC101927872 Neighboring gene MAPRE1 pseudogene 1 Neighboring gene RNA, U1 small nuclear 35, pseudogene Neighboring gene uncharacterized LOC107986978

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of KH domain containing, RNA binding, signal transduction associated 3 (KHDRBS3) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev Overexpression of the two GSG family members, SLM1 and SLM2, enhance unspliced HIV RNA cleavage and expression PubMed
Vif vif HIV-1 Vif upregulates the expression of KH domain containing, RNA binding, signal transduction associated 3 (KHDRBS3) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
KH domain-containing, RNA-binding, signal transduction-associated protein 3
Names
KH domain containing, RNA binding, signal transduction associated 3
RNA-binding protein T-Star
Sam68-like phosphotyrosine protein, T-STAR
sam68-like mammalian protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006558.3NP_006549.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3

    See identical proteins and their annotated locations for NP_006549.1

    Status: VALIDATED

    Source sequence(s)
    AC040914, AF051321, BC032606, BC106028, CB155439
    Consensus CDS
    CCDS6374.1
    UniProtKB/Swiss-Prot
    O75525
    Related
    ENSP00000348108.5, ENST00000355849.10
    Conserved Domains (3) summary
    cd02395
    Location:58177
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:553
    Qua1; Qua1 domain
    pfam16568
    Location:266320
    Sam68-YY; Tyrosine-rich domain of Sam68

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    135457456..135656516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516798.1XP_011515100.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X4

    Conserved Domains (2) summary
    cd02395
    Location:58177
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:553
    Qua1; Qua1 domain
  2. XM_005250758.3XP_005250815.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X5

    See identical proteins and their annotated locations for XP_005250815.1

    Conserved Domains (3) summary
    cd02395
    Location:58177
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:553
    Qua1; Qua1 domain
    pfam16568
    Location:266296
    Sam68-YY; Tyrosine-rich domain of Sam68
  3. XM_011516799.1XP_011515101.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X8

    Conserved Domains (2) summary
    cd02395
    Location:58177
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:553
    Qua1; Qua1 domain
  4. XM_005250757.3XP_005250814.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X3

    Conserved Domains (3) summary
    cd02395
    Location:30149
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:225
    Qua1; Qua1 domain
    pfam16568
    Location:238292
    Sam68-YY; Tyrosine-rich domain of Sam68
  5. XM_024447052.1XP_024302820.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X6

    Related
    ENSP00000431022.1, ENST00000524199.5
    Conserved Domains (3) summary
    cd02395
    Location:30149
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:225
    Qua1; Qua1 domain
    pfam16568
    Location:238268
    Sam68-YY; Tyrosine-rich domain of Sam68
  6. XM_011516797.2XP_011515099.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011515099.1

    Conserved Domains (3) summary
    cd02395
    Location:31150
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:326
    Qua1; Qua1 domain
    pfam16568
    Location:239293
    Sam68-YY; Tyrosine-rich domain of Sam68
  7. XM_011516796.3XP_011515098.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X1

    Conserved Domains (3) summary
    cd02395
    Location:58177
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:2553
    Qua1; Qua1 domain
    pfam16568
    Location:266320
    Sam68-YY; Tyrosine-rich domain of Sam68
  8. XM_024447053.1XP_024302821.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X7

    Conserved Domains (2) summary
    pfam16568
    Location:172226
    Sam68-YY; Tyrosine-rich domain of Sam68
    cl00098
    Location:183
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

RNA

  1. XR_242372.2 RNA Sequence

  2. XR_001745458.1 RNA Sequence

  3. XR_928287.1 RNA Sequence

  4. XR_001745455.1 RNA Sequence

  5. XR_242374.3 RNA Sequence

  6. XR_001745457.1 RNA Sequence

  7. XR_001745456.1 RNA Sequence

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