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Tecr trans-2,3-enoyl-CoA reductase [ Mus musculus (house mouse) ]

Gene ID: 106529, updated on 5-Feb-2023

Summary

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Official Symbol
Tecrprovided by MGI
Official Full Name
trans-2,3-enoyl-CoA reductaseprovided by MGI
Primary source
MGI:MGI:1915408
See related
Ensembl:ENSMUSG00000031708 AllianceGenome:MGI:1915408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SC2; Gpsn2; D17Ertd178e; 2410016D23Rik; A230102P12Rik
Summary
Predicted to enable very-long-chain enoyl-CoA reductase activity. Predicted to be involved in fatty acid elongation; sphingolipid metabolic process; and very long-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process and steroid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TECR (trans-2,3-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 340.9), mammary gland adult (RPKM 233.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tecr in Genome Data Viewer
Location:
8 C2; 8 40.22 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84298327..84321120, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83571698..83594491, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B7 Neighboring gene RIKEN cDNA D830024N08 gene Neighboring gene predicted gene, 51541 Neighboring gene predicted gene, 42029 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a mouse synaptic glycoprotein gene in cultured neurons. Yu AC, et al. Neurochem Res, 2005 Oct. PMID 16341590
  2. Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. Moon YA, et al. J Biol Chem, 2003 Feb 28. PMID 12482854
  3. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Nguyen TD, et al. Blood, 2019 Jan 10. PMID 30498063
  4. Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Sultana DA, et al. Blood, 2009 Mar 26. PMID 19164599, Free PMC Article
  5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647

See all (38) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe the sequence and distribution of mouse synaptic glycoprotein homolog 2.
    Title: Identification of a mouse synaptic glycoprotein gene in cultured neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144249

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain enoyl-CoA reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in very long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
very-long-chain enoyl-CoA reductase
Names
TER
glycoprotein, synaptic 2
synaptic glycoprotein SC2
NP_081455.1
NP_598879.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027179.1 → NP_081455.1  very-long-chain enoyl-CoA reductase isoform 2

    See identical proteins and their annotated locations for NP_081455.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK010984, BE994003, BY278351
    Consensus CDS
    CCDS52609.1
    UniProtKB/Swiss-Prot
    Q9CY27
    UniProtKB/TrEMBL
    A0A6P7RHD5, G3UWE1
    Related
    ENSMUSP00000131389.2, ENSMUST00000165740.9
    Conserved Domains (2) summary
    PLN02560
    Location:38 → 290
    PLN02560; enoyl-CoA reductase
    cl28922
    Location:3 → 66
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. NM_134118.5 → NP_598879.1  very-long-chain enoyl-CoA reductase isoform 1

    See identical proteins and their annotated locations for NP_598879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK010984, BE994003, BY278351
    Consensus CDS
    CCDS40403.1
    UniProtKB/Swiss-Prot
    Q9CY27
    UniProtKB/TrEMBL
    A0A6P5Q272
    Related
    ENSMUSP00000019382.10, ENSMUST00000019382.17
    Conserved Domains (1) summary
    PLN02560
    Location:23 → 305
    PLN02560; enoyl-CoA reductase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84298327..84321120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY27.1 GenPept UniProtKB/Swiss-Prot:Q9CY27

Gene LinkOut

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