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Stk38 serine/threonine kinase 38 [ Mus musculus (house mouse) ]

Gene ID: 106504, updated on 8-Nov-2022

Summary

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Official Symbol
Stk38provided by MGI
Official Full Name
serine/threonine kinase 38provided by MGI
Primary source
MGI:MGI:2442572
See related
Ensembl:ENSMUSG00000024006 AllianceGenome:MGI:2442572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndr1; 5830476G13Rik; 9530097A09Rik
Summary
Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Predicted to be involved in intracellular signal transduction; negative regulation of MAP kinase activity; and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and nose. Orthologous to human STK38 (serine/threonine kinase 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 16.0), thymus adult (RPKM 15.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stk38 in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29189854..29226979, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28970880..29008010, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16191 Neighboring gene peroxisomal, testis specific 1 Neighboring gene potassium channel tetramerisation domain containing 20 Neighboring gene predicted gene, 23887 Neighboring gene predicted gene 16196 Neighboring gene serine and arginine-rich splicing factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia. Wang H, et al. Bioengineered, 2021 Dec. PMID 34699306, Free PMC Article
  2. Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes. Liu J, et al. Sci Rep, 2017 Mar 21. PMID 28322254, Free PMC Article
  3. The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility. Tang F, et al. Sci Signal, 2015 Oct 6. PMID 26443704
  4. Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages. Wen M, et al. Nat Commun, 2015 May 18. PMID 25981615
  5. Identification of a Novel Link between the Protein Kinase NDR1 and TGFβ Signaling in Epithelial Cells. Pot I, et al. PLoS One, 2013. PMID 23840619, Free PMC Article

See all (40) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia.
    Title: Molecular Mechanism of Biofilm Locator Protein Kinase Dbf2p-related kinase 1 in Regulating Innate Immune Response to Interleukin 17-induced Viral Pneumonia.
  2. These results revealed that Stk38 kinase catalyzes the phosphorylation of Rbm24 during sarcomerogensis and this orchestrates accurate sarcomere alignment.
    Title: Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes.
  3. a novel and intimate link between the protein kinase NDR1 and TGFbeta signaling
    Title: Identification of a Novel Link between the Protein Kinase NDR1 and TGFβ Signaling in Epithelial Cells.
  4. Stk38 protein kinase has a role in inhibiting TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages
    Title: Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages.
  5. Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling.
    Title: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
  6. reduction in the abundances of the NDR proteins NDR1 and NDR2 results in defective responses to proapoptotic stimuli, thereby facilitating the development of tumors
    Title: Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 38
Names
NDR1 protein kinase
nuclear Dbf2-related kinase 1
NP_001344102.1
NP_598876.1
XP_011244534.1
XP_011244535.1
XP_030105270.1
XP_030105271.1
XP_036016133.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357173.1 → NP_001344102.1  serine/threonine-protein kinase 38

    Status: VALIDATED

    Source sequence(s)
    AY292399, BE686860, BY750361, CT025867, CX202466
    Consensus CDS
    CCDS28589.1
    UniProtKB/Swiss-Prot
    Q91VJ4
    UniProtKB/TrEMBL
    A0A8C6MTF2
    Related
    ENSMUSP00000113657.2, ENSMUST00000119274.3
    Conserved Domains (1) summary
    cd05628
    Location:87 → 462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

  2. NM_134115.3 → NP_598876.1  serine/threonine-protein kinase 38

    See identical proteins and their annotated locations for NP_598876.1

    Status: VALIDATED

    Source sequence(s)
    AC167363, BE686860, CT025867
    Consensus CDS
    CCDS28589.1
    UniProtKB/Swiss-Prot
    Q91VJ4
    UniProtKB/TrEMBL
    A0A8C6MTF2
    Related
    ENSMUSP00000009138.6, ENSMUST00000009138.13
    Conserved Domains (1) summary
    cd05628
    Location:87 → 462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29189854..29226979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249410.2 → XP_030105270.1  serine/threonine-protein kinase 38 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1 → 289
    PKc_like; Protein Kinases, catalytic domain

  2. XM_030249411.1 → XP_030105271.1  serine/threonine-protein kinase 38 isoform X3

    Related
    ENSMUSP00000156592.2, ENSMUST00000141431.8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 289
    PKc_like; Protein Kinases, catalytic domain

  3. XM_011246232.3 → XP_011244534.1  serine/threonine-protein kinase 38 isoform X2

    See identical proteins and their annotated locations for XP_011244534.1

    Conserved Domains (1) summary
    cd05628
    Location:36 → 411
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

  4. XM_011246233.3 → XP_011244535.1  serine/threonine-protein kinase 38 isoform X2

    See identical proteins and their annotated locations for XP_011244535.1

    Conserved Domains (1) summary
    cd05628
    Location:36 → 411
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

  5. XM_036160240.1 → XP_036016133.1  serine/threonine-protein kinase 38 isoform X1

    UniProtKB/Swiss-Prot
    Q91VJ4
    UniProtKB/TrEMBL
    A0A8C6MTF2
    Related
    ENSMUSP00000156711.2, ENSMUST00000232836.2
    Conserved Domains (1) summary
    cd05628
    Location:87 → 462
    STKc_NDR1; Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

RNA

  1. XR_004939455.1 RNA Sequence

  2. XR_004939456.1 RNA Sequence

    Related
    ENSMUST00000126893.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VJ4.1 GenPept UniProtKB/Swiss-Prot:Q91VJ4

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