Format

Send to:

Choose Destination

SCGB1D1 secretoglobin family 1D member 1 [ Homo sapiens (human) ]

Gene ID: 10648, updated on 23-Nov-2021

Summary

Official Symbol
SCGB1D1provided by HGNC
Official Full Name
secretoglobin family 1D member 1provided by HGNC
Primary source
HGNC:HGNC:18395
See related
Ensembl:ENSG00000168515 MIM:615060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIPA; LPHA; LPNA
Summary
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. This gene product represents one component of a heterodimeric molecule present in human tears whose elution profile is consistent with prostatein, a tetrameric molecule composed of three peptide components in heterodimers. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 15, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SCGB1D1 in Genome Data Viewer
Location:
11q12.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62190216..62193539)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61957688..61961011)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene inner centromere protein Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 8 Neighboring gene secretoglobin family 2A member 1 Neighboring gene secretoglobin family 1D member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71958

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
secretoglobin family 1D member 1
Names
lipophilin A (uteroglobin family member)
lipophilin-A
prostatein-like lipophilin A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006552.2NP_006543.1  secretoglobin family 1D member 1 precursor

    See identical proteins and their annotated locations for NP_006543.1

    Status: REVIEWED

    Source sequence(s)
    AJ224171, AP002793, AP003306
    Consensus CDS
    CCDS8015.1
    UniProtKB/Swiss-Prot
    O95968
    Related
    ENSP00000303070.3, ENST00000306238.3
    Conserved Domains (1) summary
    pfam01099
    Location:2484
    Uteroglobin; Uteroglobin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62190216..62193539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center