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SCGB1D2 secretoglobin family 1D member 2 [ Homo sapiens (human) ]

Gene ID: 10647, updated on 23-Nov-2021

Summary

Official Symbol
SCGB1D2provided by HGNC
Official Full Name
secretoglobin family 1D member 2provided by HGNC
Primary source
HGNC:HGNC:18396
See related
Ensembl:ENSG00000124935 MIM:615061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIPB; LPHB; LPNB
Summary
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2. [provided by RefSeq, Jul 2008]
Expression
Biased expression in endometrium (RPKM 23.0), prostate (RPKM 3.0) and 3 other tissues See more
Orthologs
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Genomic context

See SCGB1D2 in Genome Data Viewer
Location:
11q12.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62242239..62244812)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62009711..62012284)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene secretoglobin family 1D member 1 Neighboring gene secretoglobin family 2A member 1 Neighboring gene secretoglobin family 2A member 2 Neighboring gene secretoglobin family 1D member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
secretoglobin family 1D member 2
Names
lipophilin-B
prostatein-like lipophilin B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006551.4NP_006542.1  secretoglobin family 1D member 2 precursor

    See identical proteins and their annotated locations for NP_006542.1

    Status: REVIEWED

    Source sequence(s)
    AJ224172, AL708956, AP003306
    Consensus CDS
    CCDS8017.1
    UniProtKB/Swiss-Prot
    O95969
    Related
    ENSP00000244926.3, ENST00000244926.4
    Conserved Domains (1) summary
    pfam01099
    Location:2486
    Uteroglobin; Uteroglobin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62242239..62244812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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