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IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 10644, updated on 11-Jul-2024

Summary

Official Symbol
IGF2BP2provided by HGNC
Official Full Name
insulin like growth factor 2 mRNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:28867
See related
Ensembl:ENSG00000073792 MIM:608289; AllianceGenome:HGNC:28867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMP2; IMP-2; VICKZ2
Summary
This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
Expression
Broad expression in placenta (RPKM 4.8), colon (RPKM 4.7) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IGF2BP2 in Genome Data Viewer
Location:
3q27.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (185643130..185825042, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (188458961..188640755, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185360918..185542830, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20926 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185272617-185273292 Neighboring gene lipase H Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:185280735-185281348 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185281349-185281962 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185300277-185301176 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302322-185302941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302942-185303560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185303561-185304179 Neighboring gene SUMO specific peptidase 2 Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185359885-185360103 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185363553-185364440 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185369908-185370106 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:185406257-185407456 Neighboring gene IGF2BP2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185442702-185443202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185445539-185446390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185446391-185447242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185449611-185450110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14976 Neighboring gene uncharacterized LOC124906313 Neighboring gene Sharpr-MPRA regulatory region 9603 Neighboring gene Sharpr-MPRA regulatory region 5696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185487094-185487594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185487595-185488095 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185491440-185492292 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:185496875-185497772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185497860-185498360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185501879-185502772 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185504559-185505450 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185507237-185508130 Neighboring gene microRNA 548aq Neighboring gene VISTA enhancer hs1976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185516757-185517258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185517259-185517758 Neighboring gene NANOG hESC enhancer GRCh37_chr3:185520396-185520897 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:185525354-185525896 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185540833-185541696 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185542636-185542866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14978 Neighboring gene Sharpr-MPRA regulatory region 6530 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185623478-185623669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185655136-185655863 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185666824-185667766 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185667767-185668709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185670624-185671147 Neighboring gene transformer 2 beta homolog Neighboring gene Sharpr-MPRA regulatory region 2251 Neighboring gene NmrA like redox sensor 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Type II diabetes mellitus
MedGen: C0011860 OMIM: 125853 GeneReviews: WFS1 Spectrum Disorder
Compare labs

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
EBI GWAS Catalog
A genome-wide association study of gestational diabetes mellitus in Korean women.
EBI GWAS Catalog
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
EBI GWAS Catalog
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
EBI GWAS Catalog
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
EBI GWAS Catalog
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
EBI GWAS Catalog
Genome-wide association study identifies three novel loci for type 2 diabetes.
EBI GWAS Catalog
Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
EBI GWAS Catalog
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
EBI GWAS Catalog
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
EBI GWAS Catalog
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Rev rev Ectopic expression of IMP1 inhibits replication of HIV-1 in SupT1 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp686I17155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA reader activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables translation regulator activity, nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in CRD-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in cold-induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in energy homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cytokine production IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor 2 mRNA-binding protein 2
Names
IGF-II mRNA-binding protein 2
IGF2 mRNA-binding protein 2
VICKZ family member 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011602.1 RefSeqGene

    Range
    4998..186910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007225.3NP_001007226.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_001007226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as p62) is shorter than isoform a.
    Source sequence(s)
    AC016961, AC108670
    Consensus CDS
    CCDS33903.1
    UniProtKB/Swiss-Prot
    Q9Y6M1
    Related
    ENSP00000320204.5, ENST00000346192.7
    Conserved Domains (6) summary
    cd12626
    Location:278
    RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd12629
    Location:82157
    RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd22491
    Location:195268
    KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22497
    Location:383459
    KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22500
    Location:466543
    KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cl00098
    Location:276352
    KH-I; K homology (KH) RNA-binding domain, type I
  2. NM_001291869.3NP_001278798.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC016961, AC108670
    Consensus CDS
    CCDS77870.1
    UniProtKB/TrEMBL
    F8W930
    Related
    ENSP00000410242.2, ENST00000457616.6
    Conserved Domains (4) summary
    cd00105
    Location:283348
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:436499
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cd12626
    Location:278
    RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cl17169
    Location:82163
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_001291872.3NP_001278801.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform d

    See identical proteins and their annotated locations for NP_001278801.1

    Status: REVIEWED

    Source sequence(s)
    AC016961, AC108670, AI348863, BC021290, BX106919, EU408701
    UniProtKB/Swiss-Prot
    Q9Y6M1
    Conserved Domains (5) summary
    cd12629
    Location:19100
    RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd22491
    Location:138211
    KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22494
    Location:219295
    KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22497
    Location:369445
    KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22500
    Location:452529
    KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
  4. NM_001291873.3NP_001278802.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform e

    See identical proteins and their annotated locations for NP_001278802.1

    Status: REVIEWED

    Source sequence(s)
    AC016961, AC108670, AI348863, BC021290, BX106919, EU408702
    Consensus CDS
    CCDS77869.1
    UniProtKB/Swiss-Prot
    Q9Y6M1
    Related
    ENSP00000413787.3, ENST00000421047.3
    Conserved Domains (5) summary
    cd12629
    Location:1994
    RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd22491
    Location:132205
    KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22494
    Location:213289
    KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22497
    Location:363439
    KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22500
    Location:446523
    KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
  5. NM_001291874.3NP_001278803.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform f

    See identical proteins and their annotated locations for NP_001278803.1

    Status: REVIEWED

    Source sequence(s)
    AC016961, AC108670, AI348863, AK296703, BC021290, BX106919, EU408703
    UniProtKB/Swiss-Prot
    Q9Y6M1
    UniProtKB/TrEMBL
    B4DKT5
    Conserved Domains (4) summary
    cd12629
    Location:1994
    RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd22497
    Location:320396
    KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22500
    Location:403480
    KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cl00098
    Location:213289
    KH-I; K homology (KH) RNA-binding domain, type I
  6. NM_001291875.3NP_001278804.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC016961, AC108670, AI348863, BC021290, BX106919, EU408704
    UniProtKB/Swiss-Prot
    Q9Y6M1
    UniProtKB/TrEMBL
    B3FTN5
    Conserved Domains (3) summary
    cd00105
    Location:141206
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:294357
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cl17169
    Location:121
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. NM_006548.6NP_006539.3  insulin-like growth factor 2 mRNA-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_006539.3

    Status: REVIEWED

    Source sequence(s)
    AC016961, AI348863, AK290664, BC021290, BX106919, BY795845
    Consensus CDS
    CCDS3273.2
    UniProtKB/Swiss-Prot
    A0A4Z0, B3FTN2, B3FTN3, B3FTN4, Q9Y6M1
    Related
    ENSP00000371634.3, ENST00000382199.7
    Conserved Domains (6) summary
    cd12626
    Location:278
    RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd12629
    Location:82157
    RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd22491
    Location:195268
    KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22494
    Location:276352
    KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22497
    Location:426502
    KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22500
    Location:509586
    KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

RNA

  1. NR_138486.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate segment in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC016961, AC108670

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    185643130..185825042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447325.1XP_047303281.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X16

  2. XM_024453316.2XP_024309084.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X15

    Conserved Domains (3) summary
    cd00105
    Location:141206
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:294357
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cl17169
    Location:121
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_047447317.1XP_047303273.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X5

  4. XM_017005557.3XP_016861046.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X1

  5. XM_047447321.1XP_047303277.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X10

  6. XM_047447316.1XP_047303272.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X4

    Conserved Domains (5) summary
    cd12626
    Location:278
    RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd12629
    Location:82157
    RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd22491
    Location:195268
    KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cd22494
    Location:276352
    KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    cl00098
    Location:426487
    KH-I; K homology (KH) RNA-binding domain, type I
  7. XM_047447319.1XP_047303275.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X8

  8. XM_017005558.3XP_016861047.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X2

  9. XM_017005559.3XP_016861048.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X3

  10. XM_047447322.1XP_047303278.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X12

  11. XM_047447323.1XP_047303279.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X13

  12. XM_047447318.1XP_047303274.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X7

  13. XM_017005560.3XP_016861049.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X6

  14. XM_047447326.1XP_047303282.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X16

  15. XM_047447320.1XP_047303276.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X9

  16. XM_047447328.1XP_047303284.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X15

  17. XM_047447329.1XP_047303285.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X20

    UniProtKB/TrEMBL
    B4DKT5
  18. XM_047447330.1XP_047303286.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X21

  19. XM_047447327.1XP_047303283.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X17

  20. XM_006713477.5XP_006713540.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X19

    See identical proteins and their annotated locations for XP_006713540.1

    UniProtKB/TrEMBL
    B4DKT5
    Conserved Domains (3) summary
    cd00105
    Location:2186
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:174237
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cl02570
    Location:67112
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  21. XM_047447324.1XP_047303280.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X14

  22. XM_017005561.2XP_016861050.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X11

  23. XM_017005564.2XP_016861053.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X18

  24. XM_017005563.2XP_016861052.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X18

RNA

  1. XR_007095624.1 RNA Sequence

  2. XR_001739984.3 RNA Sequence

  3. XR_007095628.1 RNA Sequence

  4. XR_007095626.1 RNA Sequence

  5. XR_007095625.1 RNA Sequence

  6. XR_007095627.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    188458961..188640755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344981.1XP_054200956.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X16

  2. XM_054344980.1XP_054200955.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X15

  3. XM_054344970.1XP_054200945.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X5

  4. XM_054344966.1XP_054200941.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X1

  5. XM_054344975.1XP_054200950.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X10

  6. XM_054344969.1XP_054200944.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X4

  7. XM_054344973.1XP_054200948.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X8

  8. XM_054344967.1XP_054200942.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X2

  9. XM_054344968.1XP_054200943.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X3

  10. XM_054344978.1XP_054200953.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X13

  11. XM_054344971.1XP_054200946.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X6

  12. XM_054344972.1XP_054200947.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X7

  13. XM_054344977.1XP_054200952.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X12

  14. XM_054344974.1XP_054200949.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X9

  15. XM_054344986.1XP_054200961.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X15

  16. XM_054344987.1XP_054200962.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X20

    UniProtKB/TrEMBL
    B4DKT5
  17. XM_054344988.1XP_054200963.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X21

  18. XM_054344982.1XP_054200957.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X17

  19. XM_054344985.1XP_054200960.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X19

    UniProtKB/TrEMBL
    B4DKT5
  20. XM_054344979.1XP_054200954.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X14

  21. XM_054344976.1XP_054200951.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X11

  22. XM_054344984.1XP_054200959.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X18

  23. XM_054344983.1XP_054200958.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X18

RNA

  1. XR_008486631.1 RNA Sequence

  2. XR_008486630.1 RNA Sequence

  3. XR_008486635.1 RNA Sequence

  4. XR_008486633.1 RNA Sequence

  5. XR_008486632.1 RNA Sequence

  6. XR_008486634.1 RNA Sequence