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IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 [ Homo sapiens (human) ]

Gene ID: 10644, updated on 8-Dec-2018

Summary

Official Symbol
IGF2BP2provided by HGNC
Official Full Name
insulin like growth factor 2 mRNA binding protein 2provided by HGNC
Primary source
HGNC:HGNC:28867
See related
Ensembl:ENSG00000073792 MIM:608289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMP2; IMP-2; VICKZ2
Summary
This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
Expression
Broad expression in placenta (RPKM 4.8), colon (RPKM 4.7) and 24 other tissues See more
Orthologs

Genomic context

See IGF2BP2 in Genome Data Viewer
Location:
3q27.2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (185643131..185825056, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185361527..185542827, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986055 Neighboring gene SUMO specific peptidase 2 Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene IGF2BP2 antisense RNA 1 Neighboring gene microRNA 548aq Neighboring gene transformer 2 beta homolog Neighboring gene NmrA like redox sensor 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Diabetes mellitus type 2
MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog
A genome-wide association study of gestational diabetes mellitus in Korean women.
NHGRI GWA Catalog
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
NHGRI GWA Catalog
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
NHGRI GWA Catalog
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
NHGRI GWA Catalog
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
NHGRI GWA Catalog
Genome-wide association study identifies three novel loci for type 2 diabetes.
NHGRI GWA Catalog
Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
NHGRI GWA Catalog
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
NHGRI GWA Catalog
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
NHGRI GWA Catalog
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Interaction of HIV-1 Gag with insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is identified in a series of six affinity purification/mass spectrometry screens PubMed
Rev rev Ectopic expression of IMP1 inhibits replication of HIV-1 in SupT1 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686I17155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of cytokine biosynthetic process IC
Inferred by Curator
more info
PubMed 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor 2 mRNA-binding protein 2
Names
IGF-II mRNA-binding protein 2
IGF2 mRNA-binding protein 2
VICKZ family member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011602.1 RefSeqGene

    Range
    4984..186909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007225.2NP_001007226.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_001007226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as p62) is shorter than isoform a.
    Source sequence(s)
    AC016961, AC108670
    Consensus CDS
    CCDS33903.1
    UniProtKB/Swiss-Prot
    Q9Y6M1
    Related
    ENSP00000320204.5, ENST00000346192.7
    Conserved Domains (5) summary
    cd00105
    Location:277342
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:387450
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cd12626
    Location:278
    RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd12629
    Location:82157
    RRM2_IGF2BP2; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    pfam00013
    Location:471534
    KH_1; KH domain
  2. NM_001291869.2NP_001278798.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC016961, AC108670
    Consensus CDS
    CCDS77870.1
    UniProtKB/TrEMBL
    F8W930
    Related
    ENSP00000410242.2, ENST00000457616.6
    Conserved Domains (4) summary
    cd00105
    Location:283348
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:436499
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cd12626
    Location:278
    RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cl17169
    Location:82163
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_001291872.2NP_001278801.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform d

    See identical proteins and their annotated locations for NP_001278801.1

    Status: REVIEWED

    Source sequence(s)
    AC016961, AI348863, BC021290, BX106919, EU408701
    UniProtKB/Swiss-Prot
    Q9Y6M1
    Conserved Domains (5) summary
    COG0724
    Location:18140
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00105
    Location:139202
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:373436
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cl02570
    Location:266311
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl17169
    Location:19100
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. NM_001291873.2NP_001278802.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform e

    See identical proteins and their annotated locations for NP_001278802.1

    Status: REVIEWED

    Source sequence(s)
    AC016961, AI348863, BC021290, BX106919, EU408702
    Consensus CDS
    CCDS77869.1
    UniProtKB/Swiss-Prot
    Q9Y6M1
    Related
    ENSP00000413787.3, ENST00000421047.3
    Conserved Domains (4) summary
    cd00105
    Location:214279
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:367430
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cd12629
    Location:1994
    RRM2_IGF2BP2; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    pfam00013
    Location:451514
    KH_1; KH domain
  5. NM_001291874.2NP_001278803.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform f

    See identical proteins and their annotated locations for NP_001278803.1

    Status: REVIEWED

    Source sequence(s)
    AC016961, AI348863, AK296703, BC021290, BX106919, EU408703
    UniProtKB/Swiss-Prot
    Q9Y6M1
    UniProtKB/TrEMBL
    B4DKT5
    Conserved Domains (4) summary
    COG0724
    Location:18134
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00105
    Location:214279
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:324387
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cd12629
    Location:1994
    RRM2_IGF2BP2; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
  6. NM_001291875.2NP_001278804.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC016961, AI348863, BC021290, BX106919, EU408704
    UniProtKB/Swiss-Prot
    Q9Y6M1
    UniProtKB/TrEMBL
    B3FTN5
    Conserved Domains (4) summary
    cd00105
    Location:60123
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:294357
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:378441
    KH_1; KH domain
    cl17169
    Location:121
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. NM_006548.5NP_006539.3  insulin-like growth factor 2 mRNA-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_006539.3

    Status: REVIEWED

    Source sequence(s)
    AC016961, AI348863, AK290664, BC021290, BX106919, BY795845
    Consensus CDS
    CCDS3273.2
    UniProtKB/Swiss-Prot
    Q9Y6M1
    Related
    ENSP00000371634.2, ENST00000382199.6
    Conserved Domains (5) summary
    cd00105
    Location:196259
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:430493
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cd12626
    Location:278
    RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    cd12629
    Location:82157
    RRM2_IGF2BP2; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
    pfam00013
    Location:514577
    KH_1; KH domain

RNA

  1. NR_138486.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate segment in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC016961, AC108670

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    185643131..185825056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453316.1XP_024309084.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X7

    Conserved Domains (4) summary
    cd00105
    Location:60123
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:294357
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    pfam00013
    Location:378441
    KH_1; KH domain
    cl17169
    Location:121
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_017005560.2XP_016861049.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X4

  3. XM_017005557.2XP_016861046.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X1

  4. XM_017005559.2XP_016861048.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X3

  5. XM_017005558.2XP_016861047.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X2

  6. XM_006713477.4XP_006713540.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X9

    See identical proteins and their annotated locations for XP_006713540.1

    Conserved Domains (3) summary
    cd00105
    Location:2186
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:174237
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    cl02570
    Location:67112
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  7. XM_006713478.4XP_006713541.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X10

    Conserved Domains (2) summary
    cd00105
    Location:2186
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:131194
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
  8. XM_017005562.1XP_016861051.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X6

  9. XM_017005561.1XP_016861050.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X5

  10. XM_017005564.1XP_016861053.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X8

  11. XM_017005563.1XP_016861052.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X8

RNA

  1. XR_001739984.2 RNA Sequence

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