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NPRL2 NPR2 like, GATOR1 complex subunit [ Homo sapiens (human) ]

Gene ID: 10641, updated on 24-Nov-2020

Summary

Official Symbol
NPRL2provided by HGNC
Official Full Name
NPR2 like, GATOR1 complex subunitprovided by HGNC
Primary source
HGNC:HGNC:24969
See related
Ensembl:ENSG00000114388 MIM:607072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPR2; NPR2L; TUSC4; FFEVF2
Expression
Ubiquitous expression in lymph node (RPKM 7.6), ovary (RPKM 7.3) and 25 other tissues See more
Orthologs

Genomic context

See NPRL2 in Genome Data Viewer
Location:
3p21.31
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (50347330..50350821, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50384918..50388486, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RASSF1 antisense RNA 1 Neighboring gene Ras association domain family member 1 Neighboring gene zinc finger MYND-type containing 10 Neighboring gene cytochrome b561 family member D2 Neighboring gene transmembrane protein 115 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 2 Neighboring gene RNA, 5S ribosomal pseudogene 131

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
GATOR1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GATOR1 complex IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GATOR complex protein NPRL2
Names
2810446G01Rik
G21 protein
NPR2-like protein
gene 21 protein
homologous to yeast nitrogen permease (candidate tumor suppressor)
nitrogen permease regulator 2-like protein
tumor suppressor candidate 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006545.5NP_006536.3  GATOR complex protein NPRL2

    See identical proteins and their annotated locations for NP_006536.3

    Status: VALIDATED

    Source sequence(s)
    AC002481, BC008802, BC056861
    Consensus CDS
    CCDS2826.1
    UniProtKB/Swiss-Prot
    Q8WTW4
    Related
    ENSP00000232501.3, ENST00000232501.8
    Conserved Domains (1) summary
    cl24021
    Location:7370
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    50347330..50350821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264808.5XP_005264865.1  GATOR complex protein NPRL2 isoform X2

    Conserved Domains (1) summary
    cl24021
    Location:3250
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3
  2. XM_017005555.1XP_016861044.1  GATOR complex protein NPRL2 isoform X2

    Conserved Domains (1) summary
    cl24021
    Location:3250
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3
  3. XM_011533288.3XP_011531590.1  GATOR complex protein NPRL2 isoform X1

    Conserved Domains (1) summary
    cl24021
    Location:45367
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3
  4. XM_017005556.2XP_016861045.1  GATOR complex protein NPRL2 isoform X2

    Conserved Domains (1) summary
    cl24021
    Location:3250
    NPR3; Nitrogen Permease regulator of amino acid transport activity 3

RNA

  1. XR_001739982.1 RNA Sequence

    Related
    ENST00000667046.1
  2. XR_001739981.1 RNA Sequence

    Related
    ENST00000479512.5
  3. XR_001739983.1 RNA Sequence

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