U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eaf2 ELL associated factor 2 [ Mus musculus (house mouse) ]

Gene ID: 106389, updated on 8-Dec-2022

Summary

Official Symbol
Eaf2provided by MGI
Official Full Name
ELL associated factor 2provided by MGI
Primary source
MGI:MGI:2146616
See related
Ensembl:ENSMUSG00000022838 AllianceGenome:MGI:2146616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
U19; Festa; Traits; FESTA-L; FESTA-S
Summary
Predicted to enable transcription elongation regulator activity. Acts upstream of or within negative regulation of cell growth; negative regulation of epithelial cell proliferation involved in prostate gland development; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human EAF2 (ELL associated factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.1), kidney adult (RPKM 1.0) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Eaf2 in Genome Data Viewer
Location:
16; 16 B3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36613246..36695275, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36792884..36875068, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RNA guanylyltransferase and 5'-phosphatase pseudogene Neighboring gene solute carrier family 15 (H+/peptide transporter), member 2 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene IQ calmodulin-binding motif containing 1 Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene golgi autoantigen, golgin subfamily b, macrogolgin 1 Neighboring gene hematopoietic cell specific Lyn substrate 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription elongation factor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of super elongation complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ELL-associated factor 2
Names
ehrlich S-II transcriptional activator factor
testosterone regulated apoptosis inducer and tumor suppressor
testosterone-regulated apoptosis inducer and tumor suppressor protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113401.1NP_001106872.1  ELL-associated factor 2 isoform b

    See identical proteins and their annotated locations for NP_001106872.1

    Status: VALIDATED

    Source sequence(s)
    AC117662, AY034479, BG144504
    Consensus CDS
    CCDS49843.1
    UniProtKB/Swiss-Prot
    Q91ZD6, Q99KD2
    Related
    ENSMUSP00000110477.3, ENSMUST00000114829.9
    Conserved Domains (1) summary
    pfam09816
    Location:17113
    EAF; RNA polymerase II transcription elongation factor
  2. NM_001113405.1NP_001106876.1  ELL-associated factor 2 isoform a

    See identical proteins and their annotated locations for NP_001106876.1

    Status: VALIDATED

    Source sequence(s)
    AB081298, AC117662, AY049021
    Consensus CDS
    CCDS37335.1
    UniProtKB/Swiss-Prot
    Q91ZD6
    Related
    ENSMUSP00000110473.2, ENSMUST00000114825.3
  3. NM_001358102.1NP_001345031.1  ELL-associated factor 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC117662, AC154232
    Consensus CDS
    CCDS37335.1
  4. NM_134111.2NP_598872.1  ELL-associated factor 2 isoform a

    See identical proteins and their annotated locations for NP_598872.1

    Status: VALIDATED

    Source sequence(s)
    BC056626
    Consensus CDS
    CCDS37335.1
    UniProtKB/Swiss-Prot
    Q91ZD6
    Related
    ENSMUSP00000075331.6, ENSMUST00000075946.12

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36613246..36695275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521685.5XP_006521748.1  ELL-associated factor 2 isoform X3

    See identical proteins and their annotated locations for XP_006521748.1

    UniProtKB/Swiss-Prot
    Q91ZD6
  2. XM_036159730.1XP_036015623.1  ELL-associated factor 2 isoform X3

  3. XM_006521682.4XP_006521745.1  ELL-associated factor 2 isoform X1

    See identical proteins and their annotated locations for XP_006521745.1

    UniProtKB/TrEMBL
    K4DI60
    Related
    ENSMUSP00000023537.6, ENSMUST00000023537.6
    Conserved Domains (1) summary
    pfam09816
    Location:17115
    EAF; RNA polymerase II transcription elongation factor
  4. XM_036159731.1XP_036015624.1  ELL-associated factor 2 isoform X3

  5. XM_006521683.1XP_006521746.1  ELL-associated factor 2 isoform X3

    See identical proteins and their annotated locations for XP_006521746.1

    UniProtKB/Swiss-Prot
    Q91ZD6
  6. XM_011245800.3XP_011244102.1  ELL-associated factor 2 isoform X2

    See identical proteins and their annotated locations for XP_011244102.1

    Conserved Domains (1) summary
    pfam09816
    Location:17115
    EAF; RNA polymerase II transcription elongation factor

RNA

  1. XR_003951743.2 RNA Sequence