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LEFTY1 left-right determination factor 1 [ Homo sapiens (human) ]

Gene ID: 10637, updated on 1-Jun-2020

Summary

Official Symbol
LEFTY1provided by HGNC
Official Full Name
left-right determination factor 1provided by HGNC
Primary source
HGNC:HGNC:6552
See related
Ensembl:ENSG00000243709 MIM:603037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEFTB; LEFTYB
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016]
Expression
Biased expression in colon (RPKM 67.2), pancreas (RPKM 11.8) and 2 other tissues See more
Orthologs

Genomic context

See LEFTY1 in Genome Data Viewer
Location:
1q42.12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (225886282..225889146, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226073982..226076846, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene left-right determination factor 2 pseudogene Neighboring gene epoxide hydrolase 1 Neighboring gene transmembrane protein 63A Neighboring gene CRISPRi-validated cis-regulatory element chr1.11973 Neighboring gene microRNA 6741 Neighboring gene pyrroline-5-carboxylate reductase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of left-right determination factor 1 (LEFTY1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PYCR2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
determination of left/right symmetry ISS
Inferred from Sequence or Structural Similarity
more info
 
heart morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
left-right determination factor 1
Names
left-right determination factor B
protein lefty-1
protein lefty-B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020997.4NP_066277.1  left-right determination factor 1 preproprotein

    See identical proteins and their annotated locations for NP_066277.1

    Status: REVIEWED

    Source sequence(s)
    AF081512, AK222714
    Consensus CDS
    CCDS1548.1
    UniProtKB/Swiss-Prot
    O75610
    Related
    ENSP00000272134.5, ENST00000272134.5
    Conserved Domains (2) summary
    pfam00019
    Location:263353
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:106214
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    225886282..225889146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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