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ATP5MG ATP synthase membrane subunit g [ Homo sapiens (human) ]

Gene ID: 10632, updated on 9-Feb-2020

Summary

Official Symbol
ATP5MGprovided by HGNC
Official Full Name
ATP synthase membrane subunit gprovided by HGNC
Primary source
HGNC:HGNC:14247
See related
Ensembl:ENSG00000167283 MIM:617473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATP5L; ATP5JG
Summary
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in heart (RPKM 88.2), kidney (RPKM 80.7) and 25 other tissues See more
Orthologs

Genomic context

See ATP5MG in Genome Data Viewer
Location:
11q23.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (118401389..118409847)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118272104..118280562)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD3g molecule Neighboring gene ubiquitination factor E4A Neighboring gene uncharacterized LOC100131626 Neighboring gene lysine methyltransferase 2A Neighboring gene uncharacterized LOC101929089 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene transmembrane protein 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transporter activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process TAS
Traceable Author Statement
more info
 
ATP synthesis coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cristae formation TAS
Traceable Author Statement
more info
 
mitochondrial ATP synthesis coupled proton transport IC
Inferred by Curator
more info
PubMed 
mitochondrial ATP synthesis coupled proton transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ATP synthase subunit g, mitochondrial
Names
ATP synthase g chain, mitochondrial
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G
ATP synthase, H+ transporting, mitochondrial F1F0, subunit g
ATP synthase, H+ transporting, mitochondrial Fo complex subunit G
ATPase subunit G
F1F0-type ATP synthase subunit g
F1Fo-ATP synthase complex Fo membrane domain g subunit
NP_006467.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006476.5NP_006467.4  ATP synthase subunit g, mitochondrial

    See identical proteins and their annotated locations for NP_006467.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and is protein coding.
    Source sequence(s)
    AA258888, AI337729, BC070165
    Consensus CDS
    CCDS8397.1
    UniProtKB/Swiss-Prot
    O75964
    Related
    ENSP00000300688.3, ENST00000300688.8
    Conserved Domains (1) summary
    pfam04718
    Location:16102
    ATP-synt_G; Mitochondrial ATP synthase g subunit

RNA

  1. NR_033759.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA258888, AI337729, BC015128, BU953217

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    118401389..118409847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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