Format

Send to:

Choose Destination

PDPN podoplanin [ Homo sapiens (human) ]

Gene ID: 10630, updated on 23-Nov-2017
Official Symbol
PDPNprovided by HGNC
Official Full Name
podoplaninprovided by HGNC
Primary source
HGNC:HGNC:29602
See related
Ensembl:ENSG00000162493 MIM:608863; Vega:OTTHUMG00000007912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T1A; GP36; GP40; Gp38; OTS8; T1A2; TI1A; T1A-2; AGGRUS; HT1A-1; PA2.26
Summary
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 41.5), urinary bladder (RPKM 20.1) and 13 other tissues See more
Orthologs
Location:
1p36.21
Exon count:
8
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (13583757..13617957)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (13910252..13944452)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 38 Neighboring gene uncharacterized LOC107984918 Neighboring gene bromodomain and WD repeat domain containing 1 pseudogene 1 Neighboring gene uncharacterized LOC107984919 Neighboring gene RNA, 5S ribosomal pseudogene 41 Neighboring gene uncharacterized LOC105378612

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
    GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
chemokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT folic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT water channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT water transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin-mediated cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT folic acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
invadopodium organization IDA
Inferred from Direct Assay
more info
PubMed 
lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
lymph node development ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphangiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphatic endothelial cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet activation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular component movement ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extracellular matrix disassembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of platelet aggregation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of myofibroblast contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT water transport ISS
Inferred from Sequence or Structural Similarity
more info
 
wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
filopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
invadopodium IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
leading edge of lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
tetraspanin-enriched microdomain IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
podoplanin
Names
PA2.26 antigen
T1-alpha
glycoprotein 36
glycoprotein, 36-KD
hT1alpha-1
hT1alpha-2
lung type I cell membrane associated glycoprotein
lung type-I cell membrane-associated glycoprotein (T1A-2)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006624.1NP_001006625.1  podoplanin isoform c

    See identical proteins and their annotated locations for NP_001006625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    AF390106, AK075327, AK075345, AW022996, AY194238, BC014668, BF340649, BQ212176, BQ214601
    Consensus CDS
    CCDS44060.1
    UniProtKB/Swiss-Prot
    Q86YL7
    Related
    ENSP00000427537.1, OTTHUMP00000221498, ENST00000487038.5, OTTHUMT00000021786
    Conserved Domains (1) summary
    pfam05808
    Location:1119
    Podoplanin; Podoplanin
  2. NM_001006625.1NP_001006626.1  podoplanin isoform d

    See identical proteins and their annotated locations for NP_001006626.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), contains a distinct 5' UTR and has multiple differences in the coding region, compared to variant 1. The resulting isoform (d) is shorter and has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    AF390106, AK075327, AK075345, AW022996, AY194238, BC014668, BF340649, BQ212176, BQ214601
    Consensus CDS
    CCDS53270.1
    UniProtKB/Swiss-Prot
    Q86YL7
    Related
    ENSP00000426063.1, OTTHUMP00000221499, ENST00000475043.5, OTTHUMT00000021787
    Conserved Domains (1) summary
    pfam05808
    Location:1117
    Podoplanin; Podoplanin
  3. NM_006474.4NP_006465.3  podoplanin isoform a

    See identical proteins and their annotated locations for NP_006465.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF390106, AK075327, AK075345, AW022996, AY194238, BC014668, BE887331, BF340649
    Consensus CDS
    CCDS30602.1
    UniProtKB/Swiss-Prot
    Q86YL7
    Related
    ENSP00000479591.1, ENST00000617617.4
    Conserved Domains (1) summary
    pfam05808
    Location:77237
    Podoplanin; Podoplanin
  4. NM_198389.2NP_938203.2  podoplanin isoform b

    See identical proteins and their annotated locations for NP_938203.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF390106, AK075327, AK075345, AW022996, AY194238, BC014668, BE887331, BF340649
    Consensus CDS
    CCDS41266.1
    UniProtKB/Swiss-Prot
    Q86YL7
    Related
    ENSP00000365225.4, OTTHUMP00000009640, ENST00000376057.8, OTTHUMT00000021784
    Conserved Domains (1) summary
    pfam05808
    Location:77235
    Podoplanin; Podoplanin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

    Range
    13583757..13617957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710295.1XP_006710358.1  podoplanin isoform X1

    See identical proteins and their annotated locations for XP_006710358.1

    UniProtKB/Swiss-Prot
    Q86YL7
    Related
    ENSP00000365229.4, OTTHUMP00000221492, ENST00000376061.8, OTTHUMT00000367733
    Conserved Domains (1) summary
    pfam05808
    Location:1119
    Podoplanin; Podoplanin

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    13708939..13743119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center