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CENPF centromere protein F [ Homo sapiens (human) ]

Gene ID: 1063, updated on 19-Sep-2021

Summary

Official Symbol
CENPFprovided by HGNC
Official Full Name
centromere protein Fprovided by HGNC
Primary source
HGNC:HGNC:1857
See related
Ensembl:ENSG00000117724 MIM:600236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENF; hcp-1; CILD31; STROMS; PRO1779
Summary
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 9.7), testis (RPKM 6.0) and 15 other tissues See more
Orthologs
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Genomic context

See CENPF in Genome Data Viewer
Location:
1q41
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (214603195..214664571)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (214776538..214837914)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase non-receptor type 14 Neighboring gene adaptor related protein complex 3 subunit sigma 1 pseudogene Neighboring gene keratin 18 pseudogene 12 Neighboring gene ABHD17A pseudogene 3 Neighboring gene UBE2V1 pseudogene 13 Neighboring gene uncharacterized LOC105372916 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.
GeneReviews: Not available
Stromme syndrome
MedGen: C1855705 OMIM: 243605 GeneReviews: Not available
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates CENPF in HeLa cells within 12 hours of exposure PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chromatin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kinetochore assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in metaphase plate congression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in metaphase plate congression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of striated muscle tissue development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to xenobiotic stimulus NAS
Non-traceable Author Statement
more info
PubMed 
involved_in ventricular system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axoneme IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with chromatin NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
part_of ciliary transition fiber IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
part_of outer kinetochore TAS
Traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in pronucleus IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centromere protein F
Names
AH antigen
CENP-F kinetochore protein
cell-cycle-dependent 350K nuclear protein
centromere protein F, 350/400kDa
kinetochore protein CENPF
mitosin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046787.1 RefSeqGene

    Range
    5017..66393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016343.4NP_057427.3  centromere protein F

    See identical proteins and their annotated locations for NP_057427.3

    Status: REVIEWED

    Source sequence(s)
    BG680819, BQ774943, BU155312, BU662228, CD654009, U30872
    Consensus CDS
    CCDS31023.1
    UniProtKB/Swiss-Prot
    P49454
    Related
    ENSP00000355922.3, ENST00000366955.8
    Conserved Domains (6) summary
    COG1196
    Location:9011654
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:2831160
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR04523
    Location:23922887
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam10473
    Location:21312270
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1307
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:29673013
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    214603195..214664571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509082.3XP_011507384.1  centromere protein F isoform X2

    Conserved Domains (5) summary
    COG1196
    Location:9011654
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:2831160
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10473
    Location:21312270
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1307
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:29082954
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
  2. XM_017000086.2XP_016855575.1  centromere protein F isoform X1

    Conserved Domains (6) summary
    COG1196
    Location:9011654
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:2831160
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR04523
    Location:23922887
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam10473
    Location:21312270
    CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
    pfam10481
    Location:1307
    CENP-F_N; Cenp-F N-terminal domain
    pfam10490
    Location:29673013
    CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
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