U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

POLR3G RNA polymerase III subunit G [ Homo sapiens (human) ]

Gene ID: 10622, updated on 7-Apr-2025

Summary

Go to the top of the page Help
Official Symbol
POLR3Gprovided by HGNC
Official Full Name
RNA polymerase III subunit Gprovided by HGNC
Primary source
HGNC:HGNC:30075
See related
Ensembl:ENSG00000113356 MIM:617456; AllianceGenome:HGNC:30075
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C31; RPC7; RPC32
Summary
Enables chromatin binding activity. Involved in positive regulation of innate immune response; positive regulation of interferon-beta production; and transcription by RNA polymerase III. Acts upstream of or within cell population proliferation. Located in cytosol and nuclear body. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in testis (RPKM 1.8), esophagus (RPKM 1.0) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See POLR3G in Genome Data Viewer
Location:
5q14.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (90473929..90514557)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (90960487..91001143)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (89769746..89810374)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16167 Neighboring gene uncharacterized LOC731157 Neighboring gene centrin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22779 Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:89820083-89820584 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:89824672-89825172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22780 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:89838485-89839226 Neighboring gene NANOG hESC enhancer GRCh37_chr5:89850082-89850882 Neighboring gene NANOG hESC enhancer GRCh37_chr5:89853234-89853735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16170 Neighboring gene LysM domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:89900954-89901152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22781 Neighboring gene adhesion G protein-coupled receptor V1 Neighboring gene NANOG hESC enhancer GRCh37_chr5:89940736-89941239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:89963673-89964204 Neighboring gene NANOG hESC enhancer GRCh37_chr5:89968220-89968777 Neighboring gene uncharacterized LOC105379077 Neighboring gene NANOG hESC enhancer GRCh37_chr5:90033573-90034074

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer. Chen H, et al. FASEB J, 2023 Dec. PMID 37933949
  2. RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA(+) and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells. Lund RJ, et al. Stem Cell Reports, 2017 May 9. PMID 28494942, Free PMC Article
  3. Effects on prostate cancer cells of targeting RNA polymerase III. Petrie JL, et al. Nucleic Acids Res, 2019 May 7. PMID 30820548, Free PMC Article
  4. Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. Chantarangsu S, et al. Clin Infect Dis, 2011 Aug. PMID 21810746
  5. A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. Wong RC, et al. Stem Cells, 2011 Oct. PMID 21898682

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer.
    Title: POLR3G promotes EMT via PI3K/AKT signaling pathway in bladder cancer.
  2. A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA.
    Title: A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA.
  3. RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination.
    Title: RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination.
  4. FCER1A (rs7549785) and possibly POLR3G (rs7712322) are shown to be associated with peginterferon alfa-2a response in adult patients with chronic hepatitis B.
    Title: Genetic variation in FCER1A predicts peginterferon alfa-2a-induced hepatitis B surface antigen clearance in East Asian patients with chronic hepatitis B.
  5. Depletion of POLR3G selectively triggers proliferative arrest and differentiation of prostate cancer cells, responses not elicited when POLR3GL is depleted.
    Title: Effects on prostate cancer cells of targeting RNA polymerase III.
  6. POLR3G regulates small non-coding RNAs and RNA splicing in human pluripotent stem cells. The primary function of POLR3G is in the maintenance rather than repression of transcription.
    Title: RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of PolyA(+) and SmallRNA Transcriptomes and Splicing in Human Pluripotent Stem Cells.
  7. Decreased levels of POLR3G result in loss of pluripotency and promote differentiation of human embryonic stem cells to all three germ layers but have no effect on cell apoptosis.
    Title: A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-directed RNA polymerase activity TAS
Traceable Author Statement
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell population proliferation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase III TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase III complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DNA-directed RNA polymerase III subunit RPC7
Names
DNA-directed RNA polymerase III 32 kDa polypeptide
DNA-directed RNA polymerase III subunit G
RNA polymerase III 32 kDa apha subunit
RNA polymerase III 32 kDa subunit
RNA polymerase III subunit C7
RPC32-alpha
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
polymerase (RNA) III subunit G

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370351.1 → NP_001357280.1  DNA-directed RNA polymerase III subunit RPC7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC027323, AC093510
    Consensus CDS
    CCDS43337.1
    UniProtKB/Swiss-Prot
    A8MTH0, O15318
    UniProtKB/TrEMBL
    D6R9U7
    Related
    ENSP00000421637.1, ENST00000504930.5
    Conserved Domains (1) summary
    pfam11705
    Location:5 → 209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

  2. NM_001370352.1 → NP_001357281.1  DNA-directed RNA polymerase III subunit RPC7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC027323, AC093510
    UniProtKB/TrEMBL
    D6R9U7
    Conserved Domains (1) summary
    pfam11705
    Location:5 → 208
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

  3. NM_001370353.1 → NP_001357282.1  DNA-directed RNA polymerase III subunit RPC7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC027323, AC093510
    UniProtKB/TrEMBL
    D6R9U7
    Conserved Domains (1) summary
    pfam11705
    Location:5 → 208
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

  4. NM_001370354.1 → NP_001357283.1  DNA-directed RNA polymerase III subunit RPC7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC027323, AC093510
    Consensus CDS
    CCDS43337.1
    UniProtKB/Swiss-Prot
    A8MTH0, O15318
    UniProtKB/TrEMBL
    D6R9U7
    Related
    ENSP00000422892.1, ENST00000503373.5
    Conserved Domains (1) summary
    pfam11705
    Location:5 → 209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

  5. NM_006467.3 → NP_006458.2  DNA-directed RNA polymerase III subunit RPC7 isoform 1

    See identical proteins and their annotated locations for NP_006458.2

    Status: VALIDATED

    Source sequence(s)
    AC027323, BM788728, BP348952, CD657312
    Consensus CDS
    CCDS43337.1
    UniProtKB/Swiss-Prot
    A8MTH0, O15318
    UniProtKB/TrEMBL
    D6R9U7
    Related
    ENSP00000498469.1, ENST00000651687.1
    Conserved Domains (1) summary
    pfam11705
    Location:5 → 209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    90473929..90514557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416634.1 → XP_047272590.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

    UniProtKB/TrEMBL
    D6R9U7

  2. XM_011543101.4 → XP_011541403.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

    See identical proteins and their annotated locations for XP_011541403.1

    UniProtKB/Swiss-Prot
    A8MTH0, O15318
    UniProtKB/TrEMBL
    D6R9U7
    Conserved Domains (1) summary
    pfam11705
    Location:5 → 209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

  3. XM_047416635.1 → XP_047272591.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

    UniProtKB/TrEMBL
    D6R9U7

  4. XM_017008957.3 → XP_016864446.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

    UniProtKB/Swiss-Prot
    A8MTH0, O15318
    UniProtKB/TrEMBL
    D6R9U7
    Conserved Domains (1) summary
    pfam11705
    Location:5 → 209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

  5. XM_047416633.1 → XP_047272589.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

    UniProtKB/TrEMBL
    D6R9U7

  6. XM_047416637.1 → XP_047272593.1  DNA-directed RNA polymerase III subunit RPC7 isoform X4

  7. XM_047416636.1 → XP_047272592.1  DNA-directed RNA polymerase III subunit RPC7 isoform X3

    UniProtKB/TrEMBL
    A0A7I2R591
    Related
    ENSP00000382058.2, ENST00000399107.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    90960487..91001143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351445.1 → XP_054207420.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

    UniProtKB/TrEMBL
    D6R9U7

  2. XM_054351443.1 → XP_054207418.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

    UniProtKB/Swiss-Prot
    A8MTH0, O15318
    UniProtKB/TrEMBL
    D6R9U7

  3. XM_054351446.1 → XP_054207421.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

    UniProtKB/TrEMBL
    D6R9U7

  4. XM_054351442.1 → XP_054207417.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

    UniProtKB/Swiss-Prot
    A8MTH0, O15318
    UniProtKB/TrEMBL
    D6R9U7

  5. XM_054351444.1 → XP_054207419.1  DNA-directed RNA polymerase III subunit RPC7 isoform X2

    UniProtKB/TrEMBL
    D6R9U7

  6. XM_054351448.1 → XP_054207423.1  DNA-directed RNA polymerase III subunit RPC7 isoform X4

  7. XM_054351447.1 → XP_054207422.1  DNA-directed RNA polymerase III subunit RPC7 isoform X3

    UniProtKB/TrEMBL
    A0A7I2R591
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15318.2 GenPept UniProtKB/Swiss-Prot:O15318

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous