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POLR3G RNA polymerase III subunit G [ Homo sapiens (human) ]

Gene ID: 10622, updated on 7-Jun-2020

Summary

Official Symbol
POLR3Gprovided by HGNC
Official Full Name
RNA polymerase III subunit Gprovided by HGNC
Primary source
HGNC:HGNC:30075
See related
Ensembl:ENSG00000113356 MIM:617456
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C31; RPC7; RPC32
Expression
Broad expression in testis (RPKM 1.8), esophagus (RPKM 1.0) and 24 other tissues See more
Orthologs

Genomic context

See POLR3G in Genome Data Viewer
Location:
5q14.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (90473929..90514557)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (89769876..89810474)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC731157 Neighboring gene centrin 3 Neighboring gene metallo-beta-lactamase domain containing 2 Neighboring gene LysM domain containing 3 Neighboring gene adhesion G protein-coupled receptor V1 Neighboring gene uncharacterized LOC105379077

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase III TAS
Traceable Author Statement
more info
PubMed 
transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with nuclear chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC7
Names
DNA-directed RNA polymerase III 32 kDa polypeptide
DNA-directed RNA polymerase III subunit G
RNA polymerase III 32 kDa apha subunit
RNA polymerase III 32 kDa subunit
RNA polymerase III subunit C7
RPC32-alpha
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
polymerase (RNA) III subunit G

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370351.1NP_001357280.1  DNA-directed RNA polymerase III subunit RPC7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC027323, AC093510
    Related
    ENSP00000421637.1, ENST00000504930.5
    Conserved Domains (1) summary
    pfam11705
    Location:5209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
  2. NM_001370352.1NP_001357281.1  DNA-directed RNA polymerase III subunit RPC7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC027323, AC093510
    Conserved Domains (1) summary
    pfam11705
    Location:5208
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
  3. NM_001370353.1NP_001357282.1  DNA-directed RNA polymerase III subunit RPC7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC027323, AC093510
    Conserved Domains (1) summary
    pfam11705
    Location:5208
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
  4. NM_001370354.1NP_001357283.1  DNA-directed RNA polymerase III subunit RPC7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC027323, AC093510
    Related
    ENSP00000422892.1, ENST00000503373.5
    Conserved Domains (1) summary
    pfam11705
    Location:5209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
  5. NM_006467.3NP_006458.2  DNA-directed RNA polymerase III subunit RPC7 isoform 1

    See identical proteins and their annotated locations for NP_006458.2

    Status: VALIDATED

    Source sequence(s)
    AC027323, BM788728, BP348952, CD657312
    Consensus CDS
    CCDS43337.1
    UniProtKB/Swiss-Prot
    O15318
    UniProtKB/TrEMBL
    A0A024RAM1
    Related
    ENSP00000498469.1, ENST00000651687.1
    Conserved Domains (1) summary
    pfam11705
    Location:5209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    90473929..90514557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543101.3XP_011541403.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

    See identical proteins and their annotated locations for XP_011541403.1

    UniProtKB/Swiss-Prot
    O15318
    UniProtKB/TrEMBL
    A0A024RAM1
    Conserved Domains (1) summary
    pfam11705
    Location:5209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
  2. XM_017008957.2XP_016864446.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

    UniProtKB/Swiss-Prot
    O15318
    UniProtKB/TrEMBL
    A0A024RAM1
    Conserved Domains (1) summary
    pfam11705
    Location:5209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
  3. XM_011543102.3XP_011541404.1  DNA-directed RNA polymerase III subunit RPC7 isoform X1

    See identical proteins and their annotated locations for XP_011541404.1

    UniProtKB/Swiss-Prot
    O15318
    UniProtKB/TrEMBL
    A0A024RAM1
    Conserved Domains (1) summary
    pfam11705
    Location:5209
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
  4. XM_011543105.3XP_011541407.1  DNA-directed RNA polymerase III subunit RPC7 isoform X3

    Conserved Domains (1) summary
    pfam11705
    Location:1164
    RNA_pol_3_Rpc31; DNA-directed RNA polymerase III subunit Rpc31
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