Format

Send to:

Choose Destination

POLR3F RNA polymerase III subunit F [ Homo sapiens (human) ]

Gene ID: 10621, updated on 7-Dec-2018

Summary

Official Symbol
POLR3Fprovided by HGNC
Official Full Name
RNA polymerase III subunit Fprovided by HGNC
Primary source
HGNC:HGNC:15763
See related
Ensembl:ENSG00000132664 MIM:617455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPC6; RPC39
Summary
The protein encoded by this gene is one of more than a dozen subunits forming eukaryotic RNA polymerase III (RNA Pol III), which transcribes 5S ribosomal RNA and tRNA genes. This protein has been shown to bind both TFIIIB90 and TBP, two subunits of RNA polymerase III transcription initiation factor IIIB (TFIIIB). Unlike most of the other RNA Pol III subunits, the encoded protein is unique to this polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in brain (RPKM 6.9), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See POLR3F in Genome Data Viewer
Location:
20p11.23
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (18467389..18484648)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18448033..18465287)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene double zinc ribbon and ankyrin repeat domains 1 Neighboring gene glucosaminyl (N-acetyl) transferase 1 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 476 Neighboring gene microRNA 3192 Neighboring gene ribosomal protein L21 pseudogene 3 Neighboring gene RB binding protein 9, serine hydrolase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of polymerase (RNA) III (DNA directed) polypeptide F (POLR3F) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC13517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed 5'-3' RNA polymerase activity NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase III NAS
Non-traceable Author Statement
more info
PubMed 
transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase III complex NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase III subunit RPC6
Names
RNA polymerase III C39 subunit
RNA polymerase III subunit C6
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
polymerase (RNA) III subunit F
NP_001269455.1
NP_006457.2
XP_011527443.1
XP_016883085.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282526.1NP_001269455.1  DNA-directed RNA polymerase III subunit RPC6 isoform 2

    See identical proteins and their annotated locations for NP_001269455.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK096684, BC012588, BC016761, DA729767, N98418, U93869
    UniProtKB/Swiss-Prot
    Q9H1D9
    UniProtKB/TrEMBL
    Q05DB8
    Conserved Domains (1) summary
    pfam05158
    Location:1274
    RNA_pol_Rpc34; RNA polymerase Rpc34 subunit
  2. NM_006466.4NP_006457.2  DNA-directed RNA polymerase III subunit RPC6 isoform 1

    See identical proteins and their annotated locations for NP_006457.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL121893
    Consensus CDS
    CCDS13135.1
    UniProtKB/Swiss-Prot
    Q9H1D9
    Related
    ENSP00000366828.4, ENST00000377603.4
    Conserved Domains (1) summary
    pfam05158
    Location:12315
    RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

RNA

  1. NR_104209.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK096684, BC012588, BC016761, DA729767, N98418, U93869

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

    Range
    18467389..18484648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027596.1XP_016883085.1  DNA-directed RNA polymerase III subunit RPC6 isoform X1

  2. XM_011529141.1XP_011527443.1  DNA-directed RNA polymerase III subunit RPC6 isoform X2

    Conserved Domains (1) summary
    pfam05158
    Location:1231
    RNA_pol_Rpc34; RNA polymerase Rpc34 subunit

RNA

  1. XR_937031.1 RNA Sequence

    Related
    ENST00000462997.5
Support Center