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TGOLN2 trans-golgi network protein 2 [ Homo sapiens (human) ]

Gene ID: 10618, updated on 8-Jul-2021

Summary

Official Symbol
TGOLN2provided by HGNC
Official Full Name
trans-golgi network protein 2provided by HGNC
Primary source
HGNC:HGNC:15450
See related
Ensembl:ENSG00000152291 MIM:603062
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TGN38; TGN46; TGN48; TGN51; TTGN2; hTGN46; hTGN48; hTGN51
Summary
This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in kidney (RPKM 63.9), thyroid (RPKM 61.7) and 25 other tissues See more
Orthologs
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Genomic context

See TGOLN2 in Genome Data Viewer
Location:
2p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85318027..85327989, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85545150..85555112, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transcription factor 7 like 1 Neighboring gene SNRPE pseudogene 11 Neighboring gene uncharacterized LOC100996506 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene 2 Neighboring gene retinol saturase Neighboring gene ELMO domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag co-localizes with Rab9 and TGN38 in endosomes and trans-Golgi compartments PubMed
Vpu vpu HIV-1 Vpu co-localizes with the trans-golgi network protein TGN46 in CD4+ T cells PubMed
vpu Vpu interferes with tetherin trafficking to the cell-surface and causes a relocalization of the cellular tetherin with a TGN marker TGN46 in the TGN PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14722

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in trans-Golgi network transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in transport vesicle TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
trans-Golgi network integral membrane protein 2
Names
TGN38 homolog
trans-Golgi network glycoprotein 46
trans-Golgi network glycoprotein 48
trans-Golgi network glycoprotein 51
trans-Golgi network protein TGN51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030379.2 RefSeqGene

    Range
    5308..15270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206840.2NP_001193769.1  trans-Golgi network integral membrane protein 2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1. This variant (2, A allele) differs at 1 nt position compared to variant 2, B allele.
    Source sequence(s)
    AA723637, AC093162, AF027516, AL710137, BC008461, BY798185
    UniProtKB/Swiss-Prot
    O43493
    Conserved Domains (1) summary
    PTZ00121
    Location:55330
    PTZ00121; MAEBL; Provisional
  2. NM_001206841.2NP_001193770.1  trans-Golgi network integral membrane protein 2 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a longer and distinct C-terminus, compared to isoform 1. This variant (3, A allele) differs at 1 nt position compared to variant 3, B allele.
    Source sequence(s)
    AA723637, AC093162, AL710137, BC008461, BY798185
    Consensus CDS
    CCDS56126.1
    UniProtKB/Swiss-Prot
    O43493
    Conserved Domains (1) summary
    PTZ00121
    Location:55330
    PTZ00121; MAEBL; Provisional
  3. NM_001206844.2NP_001193773.1  trans-Golgi network integral membrane protein 2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001193773.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an in-frame segment of the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AA723637, AC093162, BC008461, BX640868
    Consensus CDS
    CCDS56127.1
    UniProtKB/Swiss-Prot
    O43493
    Related
    ENSP00000381312.2, ENST00000398263.6
    Conserved Domains (1) summary
    PLN03237
    Location:64325
    PLN03237; DNA topoisomerase 2; Provisional
  4. NM_001368095.1NP_001355024.1  trans-Golgi network integral membrane protein 2 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, B allele) differs at 1 nt position, resulting in a premature stop codon, compared to variant 2, B allele. The encoded isoform (5) is shorter than isoform 2.
    Source sequence(s)
    AC093162
    Related
    ENSP00000387035.1, ENST00000409015.5
  5. NM_001368096.1NP_001355025.1  trans-Golgi network integral membrane protein 2 isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, B allele) differs at 1 nt position compared to variant 3, A allele. The encoded isoform (6) is the same length as isoform 3 but differs in sequence by 1 aa.
    Source sequence(s)
    AC093162
    Related
    ENSP00000386443.3, ENST00000409232.7
  6. NM_006464.4NP_006455.2  trans-Golgi network integral membrane protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006455.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
    Source sequence(s)
    AA723637, AC093162, AL710137, BC008461
    Consensus CDS
    CCDS46351.1
    UniProtKB/Swiss-Prot
    O43493
    Related
    ENSP00000366603.3, ENST00000377386.8
    Conserved Domains (2) summary
    pfam17818
    Location:306435
    KCT2; Keratinocyte-associated gene product
    NF000535
    Location:40274
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    85318027..85327989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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