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TRIM3 tripartite motif containing 3 [ Homo sapiens (human) ]

Gene ID: 10612, updated on 9-Feb-2020

Summary

Official Symbol
TRIM3provided by HGNC
Official Full Name
tripartite motif containing 3provided by HGNC
Primary source
HGNC:HGNC:10064
See related
Ensembl:ENSG00000110171 MIM:605493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BERP; HAC1; RNF22; RNF97
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See TRIM3 in Genome Data Viewer
Location:
11p15.4
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (6448613..6474459, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6469843..6495689, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein binding family B member 1 Neighboring gene Sharpr-MPRA regulatory region 8482 Neighboring gene hemopexin Neighboring gene Sharpr-MPRA regulatory region 6512 Neighboring gene ADP ribosylation factor interacting protein 2 Neighboring gene translocase of inner mitochondrial membrane 10B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein C-terminus binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nervous system development TAS
Traceable Author Statement
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 3
Names
RING finger protein 97
brain expressed ring finger
brain-expressed RING finger protein
ring finger protein 22
tripartite motif protein TRIM3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001248006.1NP_001234935.1  tripartite motif-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001234935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a different 5' UTR, compared to variant 1. Variants 1, 2, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK291396, AL122053
    Consensus CDS
    CCDS7764.1
    UniProtKB/Swiss-Prot
    O75382
    Related
    ENSP00000433102.1, ENST00000525074.5
    Conserved Domains (5) summary
    smart00502
    Location:158284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:1963
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
  2. NM_001248007.1NP_001234936.1  tripartite motif-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001234936.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks several exons, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK291396, AK298843, AK299586, AL122053, BC096827
    Consensus CDS
    CCDS58115.1
    UniProtKB/Swiss-Prot
    O75382
    UniProtKB/TrEMBL
    B7Z5Y8
    Related
    ENSP00000445460.1, ENST00000536344.5
    Conserved Domains (4) summary
    smart00502
    Location:39165
    BBC; B-Box C-terminal domain
    smart00336
    Location:232
    BBOX; B-Box-type zinc finger
    smart00557
    Location:203300
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:352625
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
  3. NM_006458.3NP_006449.2  tripartite motif-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_006449.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK291396, AK299586, AL122053, BC096827, BI916995
    Consensus CDS
    CCDS7764.1
    UniProtKB/Swiss-Prot
    O75382
    UniProtKB/TrEMBL
    B7Z5Y8
    Related
    ENSP00000352508.3, ENST00000359518.7
    Conserved Domains (5) summary
    smart00502
    Location:158284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:1963
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
  4. NM_033278.4NP_150594.2  tripartite motif-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_150594.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AL122053, BC096827, BM758857, DA089323, DA347370, DB344600
    Consensus CDS
    CCDS7764.1
    UniProtKB/Swiss-Prot
    O75382
    Related
    ENSP00000340797.3, ENST00000345851.8
    Conserved Domains (5) summary
    smart00502
    Location:158284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:1963
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    6448613..6474459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448328.1XP_024304096.1  tripartite motif-containing protein 3 isoform X1

    Conserved Domains (5) summary
    smart00502
    Location:158284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:1963
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
  2. XM_017017098.2XP_016872587.1  tripartite motif-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    O75382
    Conserved Domains (5) summary
    smart00502
    Location:158284
    BBC; B-Box C-terminal domain
    smart00336
    Location:110151
    BBOX; B-Box-type zinc finger
    smart00557
    Location:322419
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:471744
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
    cd16768
    Location:1963
    RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)
  3. XM_011519845.3XP_011518147.1  tripartite motif-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_011518147.1

    UniProtKB/Swiss-Prot
    O75382
    Conserved Domains (4) summary
    smart00502
    Location:39165
    BBC; B-Box C-terminal domain
    smart00336
    Location:232
    BBOX; B-Box-type zinc finger
    smart00557
    Location:203300
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:352625
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
  4. XM_024448329.1XP_024304097.1  tripartite motif-containing protein 3 isoform X2

    Conserved Domains (4) summary
    smart00502
    Location:39165
    BBC; B-Box C-terminal domain
    smart00336
    Location:232
    BBOX; B-Box-type zinc finger
    smart00557
    Location:203300
    IG_FLMN; Filamin-type immunoglobulin domains
    cd14960
    Location:352625
    NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

RNA

  1. XR_001747732.2 RNA Sequence

  2. XR_001747734.2 RNA Sequence

  3. XR_002957118.1 RNA Sequence

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