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ST6GALNAC2 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 10610, updated on 12-Oct-2019

Summary

Official Symbol
ST6GALNAC2provided by HGNC
Official Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:10867
See related
Ensembl:ENSG00000070731 MIM:610137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STHM; SIAT7; SAITL1; SIAT7B; SIATL1; ST6GalNAII
Summary
ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 18.1), skin (RPKM 16.6) and 18 other tissues See more
Orthologs

Genomic context

See ST6GALNAC2 in Genome Data Viewer
Location:
17q25.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (76565377..76586128, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74561461..74582145, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 16 Neighboring gene small nucleolar RNA, C/D box 1B Neighboring gene small nucleolar RNA, C/D box 1A Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Neighboring gene prothymosin alpha pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45660

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
sialyltransferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sialylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Names
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase
SIAT7-B
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST6 GalNAc alpha-2,6-sialyltransferase 2
ST6GALNAC2, alpha-2,6-sialyltransferase 2
ST6GalNAc II
ST6GalNAcII
galNAc alpha-2,6-sialyltransferase II
sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide B
sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) B
sialyltransferase 7B
sialyltransferase-like 1
NP_006447.2
XP_005257011.1
XP_024306307.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006456.3NP_006447.2  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_006447.2

    Status: VALIDATED

    Source sequence(s)
    AC015802, BT019972
    Consensus CDS
    CCDS11747.1
    UniProtKB/Swiss-Prot
    Q9UJ37
    UniProtKB/TrEMBL
    A0A024R8M1
    Related
    ENSP00000225276.4, ENST00000225276.10
    Conserved Domains (1) summary
    pfam00777
    Location:111373
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    76565377..76586128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256954.4XP_005257011.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:111345
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_024450539.1XP_024306307.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:39194
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. XR_001752405.2 RNA Sequence

  2. XR_001752404.2 RNA Sequence

  3. XR_001752403.2 RNA Sequence

  4. XR_001752407.2 RNA Sequence

  5. XR_001752406.2 RNA Sequence

  6. XR_934349.2 RNA Sequence

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