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MXD4 MAX dimerization protein 4 [ Homo sapiens (human) ]

Gene ID: 10608, updated on 3-Jun-2018
Official Symbol
MXD4provided by HGNC
Official Full Name
MAX dimerization protein 4provided by HGNC
Primary source
HGNC:HGNC:13906
See related
Ensembl:ENSG00000123933 Vega:OTTHUMG00000090243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAD4; MST149; MSTP149; bHLHc12
Summary
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 22.9), spleen (RPKM 18.5) and 25 other tissues See more
Orthologs
See MXD4 in Genome Data Viewer
Location:
4p16.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (2247432..2262143, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2249160..2263739, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene HBS1 like translational GTPase pseudogene Neighboring gene DNA polymerase nu Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 5 Neighboring gene HAUS augmin like complex subunit 3 Neighboring gene microRNA 4800 Neighboring gene zinc finger FYVE-type containing 28 Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) pseudogene Neighboring gene RNA, 7SL, cytoplasmic 589, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
max dimerization protein 4
Names
Mad4 homolog
class C basic helix-loop-helix protein 12
max dimerizer 4
max-associated protein 4
max-interacting transcriptional repressor MAD4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006454.2NP_006445.1  max dimerization protein 4

    See identical proteins and their annotated locations for NP_006445.1

    Status: REVIEWED

    Source sequence(s)
    AF082740
    Consensus CDS
    CCDS3361.1
    UniProtKB/Swiss-Prot
    Q14582
    Related
    ENSP00000337889.2, OTTHUMP00000115253, ENST00000337190.6, OTTHUMT00000206519
    Conserved Domains (1) summary
    smart00353
    Location:59108
    HLH; helix loop helix domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    2247432..2262143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513388.3XP_011511690.1  max dimerization protein 4 isoform X1

    Conserved Domains (2) summary
    smart00353
    Location:120162
    HLH; helix loop helix domain
    pfam08287
    Location:148216
    DASH_Spc19; Spc19
  2. XM_017007655.1XP_016863144.1  max dimerization protein 4 isoform X2

  3. XM_017007656.2XP_016863145.1  max dimerization protein 4 isoform X3

    UniProtKB/TrEMBL
    D6RGV1
    Related
    ENSP00000421209.1, OTTHUMP00000216615, ENST00000510822.1
    Conserved Domains (1) summary
    cl26921
    Location:1283
    TraI; DNA helicase TraI

RNA

  1. XR_427467.1 RNA Sequence

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