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Fbxo4 F-box protein 4 [ Mus musculus (house mouse) ]

Gene ID: 106052, updated on 8-Feb-2024

Summary

Official Symbol
Fbxo4provided by MGI
Official Full Name
F-box protein 4provided by MGI
Primary source
MGI:MGI:2146220
See related
Ensembl:ENSMUSG00000022184 AllianceGenome:MGI:2146220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbx4; 1700096C12Rik
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; positive regulation of protein polyubiquitination; and protein destabilization. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including craniocervical region bone; esophagus; lung; pituitary gland; and sensory organ. Orthologous to human FBXO4 (F-box protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 4.2), bladder adult (RPKM 3.8) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxo4 in Genome Data Viewer
Location:
15 A1; 15 1.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (3993046..4009055, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (3963564..3979573, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene exportin 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37817 Neighboring gene STARR-seq mESC enhancer starr_37819 Neighboring gene RAB7A interacting MON1-CCZ1 complex subunit 1 Neighboring gene predicted gene 2093

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within common myeloid progenitor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134099.2NP_598860.2  F-box only protein 4

    See identical proteins and their annotated locations for NP_598860.2

    Status: VALIDATED

    Source sequence(s)
    AC137902, AI480454, BC036385
    Consensus CDS
    CCDS27359.1
    UniProtKB/Swiss-Prot
    E9QPM9, Q8CHQ0, Q99JG8
    Related
    ENSMUSP00000022791.9, ENSMUST00000022791.9
    Conserved Domains (2) summary
    cd11656
    Location:160382
    FBX4_GTPase_like; C-terminal GTPase-like domain of F-Box Only Protein 4
    pfam12937
    Location:57103
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    3993046..4009055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)