Format

Send to:

Choose Destination

PAIP1 poly(A) binding protein interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 10605, updated on 18-Aug-2020

Summary

Official Symbol
PAIP1provided by HGNC
Official Full Name
poly(A) binding protein interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:16945
See related
Ensembl:ENSG00000172239 MIM:605184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 24.5), thyroid (RPKM 20.8) and 25 other tissues See more
Orthologs

Genomic context

See PAIP1 in Genome Data Viewer
Location:
5p12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (43526267..43557411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43526369..43557521, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 267 Neighboring gene C5orf34 antisense RNA 1 Neighboring gene chromosome 5 open reading frame 34 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 19 Neighboring gene NNT antisense RNA 1 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 11344 Neighboring gene nicotinamide nucleotide transhydrogenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of poly(A) binding protein interacting protein 1 (PAIP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12360

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mRNA stabilization TAS
Traceable Author Statement
more info
PubMed 
positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
polyadenylate-binding protein-interacting protein 1
Names
PABC1-interacting protein 1
PABP-interacting protein 1
PAIP-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006451.5NP_006442.2  polyadenylate-binding protein-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006442.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC114956, BC015937, DB089732
    Consensus CDS
    CCDS3947.1
    UniProtKB/Swiss-Prot
    Q9H074
    Related
    ENSP00000302768.3, ENST00000306846.8
    Conserved Domains (2) summary
    pfam02854
    Location:160376
    MIF4G; MIF4G domain
    pfam09030
    Location:44121
    Creb_binding; Creb binding
  2. NM_182789.4NP_877590.1  polyadenylate-binding protein-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_877590.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC114956, AK308270, BC015937
    Consensus CDS
    CCDS47204.1
    UniProtKB/Swiss-Prot
    Q9H074
    Related
    ENSP00000387729.2, ENST00000436644.6
    Conserved Domains (2) summary
    pfam02854
    Location:81297
    MIF4G; MIF4G domain
    pfam07145
    Location:4461
    PAM2; Ataxin-2 C-terminal region
  3. NM_183323.3NP_899152.1  polyadenylate-binding protein-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_899152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate exon, compared to variant 1, resulting in a different 5' UTR and use of a downstream in-frame start codon. Isoform 3 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC114956, BC015937, DB089732
    Consensus CDS
    CCDS3948.1
    UniProtKB/Swiss-Prot
    Q9H074
    Related
    ENSP00000339622.4, ENST00000338972.8
    Conserved Domains (2) summary
    pfam02854
    Location:48264
    MIF4G; MIF4G domain
    pfam07145
    Location:1128
    PAM2; Ataxin-2 C-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    43526267..43557411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008956.2XP_016864445.1  polyadenylate-binding protein-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9H074
    Conserved Domains (2) summary
    pfam02854
    Location:48264
    MIF4G; MIF4G domain
    pfam07145
    Location:1128
    PAM2; Ataxin-2 C-terminal region
  2. XM_005248230.4XP_005248287.1  polyadenylate-binding protein-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005248287.1

    UniProtKB/Swiss-Prot
    Q9H074
    Conserved Domains (2) summary
    pfam02854
    Location:48264
    MIF4G; MIF4G domain
    pfam07145
    Location:1128
    PAM2; Ataxin-2 C-terminal region
Support Center