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Prickle1 prickle planar cell polarity protein 1 [ Mus musculus (house mouse) ]

Gene ID: 106042, updated on 1-Nov-2022

Summary

Official Symbol
Prickle1provided by MGI
Official Full Name
prickle planar cell polarity protein 1provided by MGI
Primary source
MGI:MGI:1916034
See related
Ensembl:ENSMUSG00000036158 AllianceGenome:MGI:1916034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pk1; mpk1; Prickle; b2b019Clo; 1110058P22Rik
Summary
Predicted to enable zinc ion binding activity. Acts upstream of or within aorta development and coronary vasculature development. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; limb; and sensory organ. Used to study autosomal recessive Robinow syndrome and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 10.0), cortex adult (RPKM 4.6) and 21 other tissues See more
Orthologs
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Genomic context

See Prickle1 in Genome Data Viewer
Location:
15; 15 E3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (93396992..93494147, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (93499111..93596266, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type and RNA binding motif 1 Neighboring gene periphilin 1 Neighboring gene predicted gene, 30181 Neighboring gene predicted gene, 41385 Neighboring gene predicted gene, 41387 Neighboring gene zinc finger protein 48, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Wnt signaling pathway, planar cell polarity pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterior visceral endoderm cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in basement membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular component organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cornea development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoskeleton-dependent intracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic nail plate morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of bipolar cell polarity involved in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extracellular matrix assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eyelid development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in face morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in focal adhesion disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesenchyme development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural tube closure ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in planar cell polarity pathway involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in polarized secretion of basement membrane proteins in epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in primitive streak formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in renal tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to electrical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tear secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell trailing edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prickle-like protein 1
Names
prickle homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033217.5NP_001028389.1  prickle-like protein 1

    See identical proteins and their annotated locations for NP_001028389.1

    Status: VALIDATED

    Source sequence(s)
    AC124592, AC126556
    Consensus CDS
    CCDS27769.1
    UniProtKB/Swiss-Prot
    Q3U5C7
    Related
    ENSMUSP00000049204.5, ENSMUST00000048982.11
    Conserved Domains (4) summary
    cd09418
    Location:189244
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:249307
    LIM3_Prickle; The third LIM domain of Prickle
    cd09483
    Location:126184
    LIM1_Prickle_1; The first LIM domain of Prickle 1
    cd09827
    Location:22118
    PET_Prickle; The PET domain of Prickle
  2. NM_001364846.1NP_001351775.1  prickle-like protein 1

    Status: VALIDATED

    Source sequence(s)
    AC126556, AK147883, AK153711
    Consensus CDS
    CCDS27769.1
    UniProtKB/Swiss-Prot
    Q3U5C7
    Related
    ENSMUSP00000104878.3, ENSMUST00000109255.3
    Conserved Domains (4) summary
    cd09418
    Location:189244
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:249307
    LIM3_Prickle; The third LIM domain of Prickle
    cd09483
    Location:126184
    LIM1_Prickle_1; The first LIM domain of Prickle 1
    cd09827
    Location:22118
    PET_Prickle; The PET domain of Prickle

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    93396992..93494147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520265.2XP_006520328.1  prickle-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006520328.1

    UniProtKB/Swiss-Prot
    Q3U5C7
    Conserved Domains (4) summary
    cd09418
    Location:189244
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:249307
    LIM3_Prickle; The third LIM domain of Prickle
    cd09483
    Location:126184
    LIM1_Prickle_1; The first LIM domain of Prickle 1
    cd09827
    Location:22118
    PET_Prickle; The PET domain of Prickle
  2. XM_006520264.5XP_006520327.1  prickle-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006520327.1

    UniProtKB/Swiss-Prot
    Q3U5C7
    Conserved Domains (4) summary
    cd09418
    Location:189244
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:249307
    LIM3_Prickle; The third LIM domain of Prickle
    cd09483
    Location:126184
    LIM1_Prickle_1; The first LIM domain of Prickle 1
    cd09827
    Location:22118
    PET_Prickle; The PET domain of Prickle
  3. XM_030248265.2XP_030104125.1  prickle-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U5C7
    Conserved Domains (4) summary
    cd09418
    Location:189244
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:249307
    LIM3_Prickle; The third LIM domain of Prickle
    cd09483
    Location:126184
    LIM1_Prickle_1; The first LIM domain of Prickle 1
    cd09827
    Location:22118
    PET_Prickle; The PET domain of Prickle