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SH2B2 SH2B adaptor protein 2 [ Homo sapiens (human) ]

Gene ID: 10603, updated on 18-Aug-2020

Summary

Official Symbol
SH2B2provided by HGNC
Official Full Name
SH2B adaptor protein 2provided by HGNC
Primary source
HGNC:HGNC:17381
See related
Ensembl:ENSG00000160999 MIM:605300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APS
Summary
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
Expression
Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.2) and 22 other tissues See more
Orthologs

Genomic context

See SH2B2 in Genome Data Viewer
Location:
7q22.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (102284525..102321711)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (101928405..101962178)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene myosin light chain 10 Neighboring gene cut like homeobox 1 Neighboring gene Sharpr-MPRA regulatory region 6241/11625 Neighboring gene uncharacterized LOC107986717 Neighboring gene microRNA 4285 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of SH2B adaptor protein 2 (SH2B2) in human B cells PubMed
Nef nef Genome-wide shRNA screening identifies SH2B2, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH2 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
antigen receptor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SH2B adapter protein 2
Names
SH2 and PH domain-containing adapter protein APS
adapter protein with pleckstrin homology and Src homology 2 domains

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033220.1 RefSeqGene

    Range
    5028..41598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001359228.2NP_001346157.1  SH2B adapter protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB000520, AC091390, BI261466, CB053166, HY020205
    Conserved Domains (3) summary
    cd10411
    Location:409504
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  2. NM_001359229.2NP_001346158.1  SH2B adapter protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB000520, AC091390, BI261466, CB053166
    Conserved Domains (3) summary
    cd10411
    Location:409504
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  3. NM_001359230.2NP_001346159.1  SH2B adapter protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA292710, AB000520, AC091390, BI261466, CB053166, HY020205
    Conserved Domains (3) summary
    cd10411
    Location:408503
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  4. NM_001359231.2NP_001346160.1  SH2B adapter protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AA292710, AB000520, AC091390, BI261466, CB053166
    Conserved Domains (3) summary
    cd10411
    Location:408503
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:193308
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:2278
    Phe_ZIP; Phenylalanine zipper
  5. NM_020979.5NP_066189.3  SH2B adapter protein 2 isoform 1

    See identical proteins and their annotated locations for NP_066189.3

    Status: REVIEWED

    Source sequence(s)
    AB000520, BF309652, BI261466, CB053166
    Consensus CDS
    CCDS78264.1
    UniProtKB/Swiss-Prot
    O14492
    UniProtKB/TrEMBL
    A0A0A0MTI2
    Related
    ENSP00000440273.3, ENST00000536178.3
    Conserved Domains (4) summary
    cd10411
    Location:452547
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:236351
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:254345
    PH; PH domain
    pfam08916
    Location:65121
    Phe_ZIP; Phenylalanine zipper

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    102284525..102321711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005276975.5XP_005277032.1  SH2B adapter protein 2 isoform X1

    Conserved Domains (4) summary
    cd10411
    Location:451546
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:236351
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:254345
    PH; PH domain
    pfam08916
    Location:65121
    Phe_ZIP; Phenylalanine zipper
  2. XM_005276976.3XP_005277033.1  SH2B adapter protein 2 isoform X2

    Conserved Domains (4) summary
    cd10411
    Location:450545
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:234349
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:252343
    PH; PH domain
    pfam08916
    Location:63119
    Phe_ZIP; Phenylalanine zipper
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