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CENPC centromere protein C [ Homo sapiens (human) ]

Gene ID: 1060, updated on 1-Jun-2020

Summary

Official Symbol
CENPCprovided by HGNC
Official Full Name
centromere protein Cprovided by HGNC
Primary source
HGNC:HGNC:1854
See related
Ensembl:ENSG00000145241 MIM:117141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIF2; hcp-4; CENP-C; CENPC1
Summary
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See CENPC in Genome Data Viewer
Location:
4q13.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (67468762..67545503, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (68337989..68411256, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 63, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 527 Neighboring gene signal transducing adaptor family member 1 Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene ubiquitin like modifier activating enzyme 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
centromeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
condensed nuclear chromosome kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
condensed nuclear chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centromere protein C
Names
CENP-C 1
centromere autoantigen C
centromere autoantigen C1
centromere protein C 1
interphase centromere complex protein 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362481.2NP_001349410.1  centromere protein C isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The encoded protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AC104806, AC109356
    Conserved Domains (3) summary
    pfam11699
    Location:848932
    CENP-C_C; Mif2/CENP-C like
    pfam15620
    Location:297551
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:7292
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
  2. NM_001812.4NP_001803.2  centromere protein C isoform 1

    See identical proteins and their annotated locations for NP_001803.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC104806, AC109356
    Consensus CDS
    CCDS47063.1
    UniProtKB/Swiss-Prot
    Q03188
    Related
    ENSP00000273853.6, ENST00000273853.11
    Conserved Domains (3) summary
    pfam11699
    Location:856940
    CENP-C_C; Mif2/CENP-C like
    pfam15620
    Location:297551
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:7292
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal

RNA

  1. NR_155754.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC104806, AC109356

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    67468762..67545503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531542.3XP_011529844.1  centromere protein C isoform X2

    Related
    ENSP00000421234.1, ENST00000513216.5
    Conserved Domains (2) summary
    pfam15620
    Location:297551
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:7292
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
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