Format

Send to:

Choose Destination

SLCO1B1 solute carrier organic anion transporter family member 1B1 [ Homo sapiens (human) ]

Gene ID: 10599, updated on 28-Nov-2021

Summary

Official Symbol
SLCO1B1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 1B1provided by HGNC
Primary source
HGNC:HGNC:10959
See related
Ensembl:ENSG00000134538 MIM:604843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LST1; HBLRR; LST-1; OATP2; OATPC; OATP-C; OATP1B1; SLC21A6
Summary
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
Expression
Restricted expression toward liver (RPKM 119.3) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SLCO1B1 in Genome Data Viewer
Location:
12p12.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (21131194..21239796)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (21284128..21392730)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A Neighboring gene solute carrier organic anion transporter family member 1C1 Neighboring gene SLCO1B3-SLCO1B7 readthrough Neighboring gene solute carrier organic anion transporter family member 1B3 Neighboring gene solute carrier organic anion transporter family member 1A2 Neighboring gene islet amyloid polypeptide Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene elongin C pseudogene 31

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide assessment of variability in human serum metabolism.
GeneReviews: Not available
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
GeneReviews: Not available
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available
Genome-wide association meta-analysis for total serum bilirubin levels.
GeneReviews: Not available
Genome-wide study of methotrexate clearance replicates SLCO1B1.
GeneReviews: Not available
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
GeneReviews: Not available
Human metabolic individuality in biomedical and pharmaceutical research.
GeneReviews: Not available
Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.
GeneReviews: Not available
Rotor syndrome
MedGen: C0220991 OMIM: 237450 GeneReviews: Rotor Syndrome
Compare labs
Simvastatin response
MedGen: CN128903 GeneReviews: Not available
Compare labs
SLCO1B1 variants and statin-induced myopathy--a genomewide study.
GeneReviews: Not available
Statin-induced myopathy
MedGen: CN181199 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133282

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bile acid and bile salt transport TAS
Traceable Author Statement
more info
 
involved_in heme catabolic process TAS
Traceable Author Statement
more info
 
involved_in organic anion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium-independent organic anion transport TAS
Traceable Author Statement
more info
 
involved_in thyroid hormone transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier organic anion transporter family member 1B1
Names
OATP-2
liver-specific organic anion transporter 1
sodium-independent organic anion-transporting polypeptide 2
solute carrier family 21 (organic anion transporter), member 6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011745.1 RefSeqGene

    Range
    5001..113603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1022

mRNA and Protein(s)

  1. NM_006446.5NP_006437.3  solute carrier organic anion transporter family member 1B1

    See identical proteins and their annotated locations for NP_006437.3

    Status: REVIEWED

    Source sequence(s)
    AC022335, AF205071, BC020696
    Consensus CDS
    CCDS8685.1
    UniProtKB/Swiss-Prot
    Q9Y6L6
    UniProtKB/TrEMBL
    A0A024RAU7, Q05CV5
    Related
    ENSP00000256958.2, ENST00000256958.3
    Conserved Domains (3) summary
    cd06174
    Location:31427
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:455508
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:29621
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    21131194..21239796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center