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Espl1 extra spindle pole bodies 1, separase [ Mus musculus (house mouse) ]

Gene ID: 105988, updated on 26-Sep-2022

Summary

Official Symbol
Espl1provided by MGI
Official Full Name
extra spindle pole bodies 1, separaseprovided by MGI
Primary source
MGI:MGI:2146156
See related
Ensembl:ENSMUSG00000058290 AllianceGenome:MGI:2146156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSE; Cerp; ESP1; PRCE
Summary
Enables cysteine-type peptidase activity. Acts upstream of or within homologous chromosome segregation; meiotic spindle organization; and mitotic sister chromatid segregation. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study breast cancer. Orthologous to human ESPL1 (extra spindle pole bodies like 1, separase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 11.7), testis adult (RPKM 11.0) and 19 other tissues See more
Orthologs
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Genomic context

See Espl1 in Genome Data Viewer
Location:
15; 15 F2
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102204688..102232792)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102296254..102324357)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9918 Neighboring gene major facilitator superfamily domain containing 5 Neighboring gene microRNA 12187 Neighboring gene prefoldin 5 Neighboring gene melanocyte proliferating gene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
separin
Names
Cut1/ESP1 related protein
caspase-like protein ESPL1
extra spindle poles-like 1 protein
separase
NP_001014976.1
NP_001343241.1
XP_006520321.1
XP_006520322.1
XP_036014955.1
XP_036014956.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014976.2NP_001014976.1  separin

    See identical proteins and their annotated locations for NP_001014976.1

    Status: VALIDATED

    Source sequence(s)
    AC163291
    Consensus CDS
    CCDS27878.1
    UniProtKB/Swiss-Prot
    A6H6E3, P60330
    Related
    ENSMUSP00000064465.5, ENSMUST00000064924.6
    Conserved Domains (1) summary
    pfam03568
    Location:17182065
    Peptidase_C50; Peptidase family C50
  2. NM_001356312.1NP_001343241.1  separin

    Status: VALIDATED

    Source sequence(s)
    AC163291
    Consensus CDS
    CCDS27878.1
    UniProtKB/Swiss-Prot
    A6H6E3
    Related
    ENSMUSP00000155304.2, ENSMUST00000229050.2
    Conserved Domains (1) summary
    pfam03568
    Location:17182065
    Peptidase_C50; Peptidase family C50

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102204688..102232792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520258.5XP_006520321.1  separin isoform X1

    See identical proteins and their annotated locations for XP_006520321.1

    UniProtKB/Swiss-Prot
    A6H6E3, P60330
    Conserved Domains (1) summary
    pfam03568
    Location:17182065
    Peptidase_C50; Peptidase family C50
  2. XM_036159062.1XP_036014955.1  separin isoform X1

    UniProtKB/Swiss-Prot
    A6H6E3
    Conserved Domains (1) summary
    pfam03568
    Location:17182065
    Peptidase_C50; Peptidase family C50
  3. XM_006520259.5XP_006520322.1  separin isoform X1

    See identical proteins and their annotated locations for XP_006520322.1

    UniProtKB/Swiss-Prot
    A6H6E3, P60330
    Conserved Domains (1) summary
    pfam03568
    Location:17182065
    Peptidase_C50; Peptidase family C50
  4. XM_036159063.1XP_036014956.1  separin isoform X2

    Conserved Domains (1) summary
    pfam03568
    Location:11791526
    Peptidase_C50; Peptidase family C50