Card10 caspase recruitment domain family, member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Card10provided by MGI
Official Full Name: caspase recruitment domain family, member 10provided by MGI
Primary source: MGI:MGI:2146012
See related: Ensembl:ENSMUSG00000033170 AllianceGenome:MGI:2146012
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bimp1; Carma3
Summary: Predicted to enable CARD domain binding activity. Predicted to be involved in activation of NF-kappaB-inducing kinase activity; negative regulation of cell migration involved in sprouting angiogenesis; and positive regulation of protein localization to nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; gut; and tooth. Orthologous to human CARD10 (caspase recruitment domain family member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 36.1), lung adult (RPKM 32.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15; 15 E1

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78659323..78687261, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (78775123..78803072, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
Title: Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
Card10 is expressed in granulocytes and is a direct target of CEBPE with functions extending to myeloid differentiation.
Title: CARD10, a CEBPE target involved in granulocytic differentiation.
CARMA3 is gradually turned over following vesicular stomatitis virus infection, which may serve as a mechanism to turn off NF-kB activation, it releases MAVS to form functional aggregates to induce interferon regulatory factor 3 activation.
Title: CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.
CARMA3 is critical for the initiation of allergic airway inflammation.
Title: CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.
Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3.Bcl10.MALT1 signalosome
Title: Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3·Bcl10·MALT1 signalosome.
the type 1 receptor for angiotensin II utilizes the CARMA3-Bcl10-MALT1 signalosome for activation of NF-kappaB in endothelial and vascular smooth muscle cells, thereby inducing pro-inflammatory signals within the vasculature
Title: The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis.
components of the CBM complex, Carma3, Bcl10, and Malt1 are key mediators of the CXCL8/IL8-induced NFkappaB activation and VEGF up-regulation.
Title: CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex.
Data demonstrate that lysophosphatidic acid stimulates thymic stromal lymphopoietin and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation.
Title: CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells.
Together, results provide the genetic evidence that CARMA3 is required for G protein-coupled receptor-induced NF-kappaB activation.
Title: CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation.
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in hepatocytes.
Title: CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237342

RH129110 (e-PCR)
- UniSTS:212418

AI449026 (e-PCR)
- UniSTS:160477

Homology

Homologs of the Card10 gene: The Card10 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Orthologs from Annotation Pipeline: 338 organisms have orthologs with human gene Card10
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of NF-kappaB-inducing kinase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of NF-kappaB-inducing kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: caspase recruitment domain-containing protein 10

Names: bcl10-interacting MAGUK protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130859.3 → NP_570929.3 caspase recruitment domain-containing protein 10

Status: VALIDATED

Source sequence(s)

AL592169

Consensus CDS

CCDS27623.2

UniProtKB/Swiss-Prot

P58660

Related

ENSMUSP00000129513.2, ENSMUST00000164826.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

78659323..78687261 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159057.1 → XP_036014950.1 caspase recruitment domain-containing protein 10 isoform X2

Conserved Domains (3) summary

COG1196
Location:270 → 573

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd08807
Location:150 → 235

CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins

cl17036
Location:822 → 884

SH3; Src Homology 3 domain superfamily
XM_036159056.1 → XP_036014949.1 caspase recruitment domain-containing protein 10 isoform X1

Related

ENSMUSP00000131003.2, ENSMUST00000170584.2

Conserved Domains (3) summary

COG1196
Location:270 → 573

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd08807
Location:150 → 235

CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins

cl17036
Location:822 → 884

SH3; Src Homology 3 domain superfamily