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Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein [ Mus musculus (house mouse) ]

Gene ID: 105837, updated on 5-Mar-2024

Summary

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Official Symbol
Mtbpprovided by MGI
Official Full Name
Mdm2, transformed 3T3 cell double minute p53 binding proteinprovided by MGI
Primary source
MGI:MGI:2146005
See related
Ensembl:ENSMUSG00000022369 AllianceGenome:MGI:2146005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MDM2BP
Summary
Acts upstream of or within negative regulation of cell population proliferation; negative regulation of mitotic nuclear division; and traversing start control point of mitotic cell cycle. Located in kinetochore. Is expressed in cerebellum; midbrain ventricular layer; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human MTBP (MDM2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 5.1), limb E14.5 (RPKM 4.4) and 21 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D1; 15 22.05 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (55420800..55489819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (55557404..55626423)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene collagen, type XIV, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_38711 Neighboring gene STARR-seq mESC enhancer starr_38712 Neighboring gene predicted gene, 18787 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene STARR-seq mESC enhancer starr_38714 Neighboring gene STARR-seq mESC enhancer starr_38715 Neighboring gene syntrophin, basic 1 Neighboring gene STARR-seq mESC enhancer starr_38716 Neighboring gene STARR-seq mESC enhancer starr_38717 Neighboring gene STARR-positive B cell enhancer ABC_E5477 Neighboring gene STARR-seq mESC enhancer starr_38718 Neighboring gene STARR-seq mESC enhancer starr_38720 Neighboring gene predicted gene, 46516

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice. Grieb BC, et al. Aging (Albany NY), 2016 Oct 30. PMID 27803394, Free PMC Article
  2. Mtbp haploinsufficiency in mice increases tumor metastasis. Iwakuma T, et al. Oncogene, 2008 Mar 20. PMID 17906694
  3. p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. Phelps M, et al. Cancer Res, 2003 May 15. PMID 12750288
  4. A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis. Odvody J, et al. Oncogene, 2010 Jun 3. PMID 20305689, Free PMC Article
  5. MTBP plays a crucial role in mitotic progression and chromosome segregation. Agarwal N, et al. Cell Death Differ, 2011 Jul. PMID 21274008, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mtbp haploinsufficiency significantly increased longevity and maximal survival in mice. Reduced levels of Mtbp did not alter locomotor activity, litter size, or body size, but Mtbp heterozygous mice did exhibit elevated markers of metabolism, particularly in the liver. Mtbp(+/-) mice also had a significant delay in spontaneous cancer development
    Title: Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice.
  2. Mtbp functioned independent of Mdm2 and was a limiting factor for the proliferative and transforming functions of Myc. Thus, Mtbp is a previously unrecognized regulator of Myc-induced tumorigenesis.
    Title: A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis.
  3. Mtbp haploinsufficiency in mice increases tumor metastasis
    Title: Mtbp haploinsufficiency in mice increases tumor metastasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic spindle checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of mitotic nuclear division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in traversing start control point of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within traversing start control point of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mdm2-binding protein
Names
mMTBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168250.1 → NP_001161722.1  mdm2-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001161722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC123682, AK133855, BB615361
    Consensus CDS
    CCDS49609.1
    UniProtKB/Swiss-Prot
    Q8BJS8
    Related
    ENSMUSP00000129396.2, ENSMUST00000170046.8
    Conserved Domains (2) summary
    pfam14918
    Location:1 → 270
    MTBP_N; MDM2-binding
    pfam14919
    Location:287 → 622
    MTBP_mid; MDM2-binding

  2. NM_001416109.1 → NP_001403038.1  mdm2-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123682

  3. NM_001416110.1 → NP_001403039.1  mdm2-binding protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123682

  4. NM_001416111.1 → NP_001403040.1  mdm2-binding protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC123682

  5. NM_001416112.1 → NP_001403041.1  mdm2-binding protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC123682

  6. NM_001416113.1 → NP_001403042.1  mdm2-binding protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC123682

  7. NM_134092.4 → NP_598853.3  mdm2-binding protein isoform 1

    See identical proteins and their annotated locations for NP_598853.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC123682
    Consensus CDS
    CCDS27478.1
    UniProtKB/Swiss-Prot
    Q80VU3, Q8BJS8, Q8BTU9, Q8BTW0, Q99K25, Q9ER61
    Related
    ENSMUSP00000022998.8, ENSMUST00000022998.14
    Conserved Domains (3) summary
    pfam14918
    Location:1 → 270
    MTBP_N; MDM2-binding
    pfam14919
    Location:287 → 626
    MTBP_mid; MDM2-binding
    pfam14920
    Location:630 → 884
    MTBP_C; MDM2-binding

RNA

  1. NR_183253.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123682

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    55420800..55489819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245394.2 → XP_011243696.1  mdm2-binding protein isoform X1

    Conserved Domains (2) summary
    pfam14918
    Location:1 → 270
    MTBP_N; MDM2-binding
    pfam14919
    Location:287 → 622
    MTBP_mid; MDM2-binding

  2. XM_017316360.3 → XP_017171849.1  mdm2-binding protein isoform X2

    Conserved Domains (2) summary
    pfam14919
    Location:1 → 296
    MTBP_mid; MDM2-binding
    pfam14920
    Location:300 → 554
    MTBP_C; MDM2-binding

  3. XM_017316361.3 → XP_017171850.1  mdm2-binding protein isoform X3

    Related
    ENSMUSP00000128615.2, ENSMUST00000169667.2
    Conserved Domains (2) summary
    pfam14919
    Location:2 → 225
    MTBP_mid; MDM2-binding
    pfam14920
    Location:229 → 483
    MTBP_C; MDM2-binding

RNA

  1. XR_383964.2 RNA Sequence

  2. XR_875211.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJS8.1 GenPept UniProtKB/Swiss-Prot:Q8BJS8

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