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Ccdc65 coiled-coil domain containing 65 [ Mus musculus (house mouse) ]

Gene ID: 105833, updated on 4-Dec-2022

Summary

Official Symbol
Ccdc65provided by MGI
Official Full Name
coiled-coil domain containing 65provided by MGI
Primary source
MGI:MGI:2146001
See related
Ensembl:ENSMUSG00000003354 AllianceGenome:MGI:2146001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NYD-SP28; 4933417K04Rik
Summary
Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be located in ciliary basal body. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Is expressed in 4th ventricle lateral recess; diencephalon roof plate; lateral ventricle choroid plexus; and olfactory epithelium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 27. Orthologous to human CCDC65 (coiled-coil domain containing 65). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 72.0) and ovary adult (RPKM 3.0) See more
Orthologs
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Genomic context

See Ccdc65 in Genome Data Viewer
Location:
15; 15 F1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98606075..98621221)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98708194..98723340)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene Rho family GTPase 1 Neighboring gene predicted gene, 34152 Neighboring gene FK506 binding protein 11 Neighboring gene ADP-ribosylation factor 3 Neighboring gene uncharacterized LOC115488470

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cilium-dependent cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cilium movement ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of axonemal dynein complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein regulatory complex subunit 2
Names
coiled-coil domain-containing protein 65
testis development protein NYD-SP28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364844.1NP_001351773.1  dynein regulatory complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK077174, BC060155
    Consensus CDS
    CCDS88835.1
    UniProtKB/TrEMBL
    A0A2R8W6P2
    Related
    ENSMUSP00000155191.2, ENSMUST00000229471.2
    Conserved Domains (1) summary
    pfam14772
    Location:29103
    NYD-SP28; Sperm tail
  2. NM_153518.2NP_705738.1  dynein regulatory complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_705738.1

    Status: VALIDATED

    Source sequence(s)
    AC156543
    Consensus CDS
    CCDS27802.1
    UniProtKB/Swiss-Prot
    Q6PAP9, Q8VHI7
    Related
    ENSMUSP00000003444.5, ENSMUST00000003444.6
    Conserved Domains (1) summary
    pfam14772
    Location:30127
    NYD-SP28; Sperm tail

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98606075..98621221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)