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IFITM2 interferon induced transmembrane protein 2 [ Homo sapiens (human) ]

Gene ID: 10581, updated on 13-Mar-2020

Summary

Official Symbol
IFITM2provided by HGNC
Official Full Name
interferon induced transmembrane protein 2provided by HGNC
Primary source
HGNC:HGNC:5413
See related
Ensembl:ENSG00000185201 MIM:605578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
1-8D; DSPA2c
Expression
Ubiquitous expression in appendix (RPKM 262.7), spleen (RPKM 209.9) and 23 other tissues See more
Orthologs

Genomic context

See IFITM2 in Genome Data Viewer
Location:
11p15.5
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (308107..309410)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (308095..309410)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene interferon induced transmembrane protein 5 Neighboring gene mitochondrial ribosomal protein S24 pseudogene 1 Neighboring gene interferon induced transmembrane protein 1 Neighboring gene interferon induced transmembrane protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 CXCR4-tropic virus replication is restricted by IFITM2 and IFITM3 as shown through shRNA knockdown PubMed
HIV-1 CCR5-tropic virus replication is restricted by IFITM1 and IFITM2 as shown through shRNA knockdown PubMed
HIV-1 infectivity is inhibited when IFITM2 is expressed by the virus producing cell (293T cells) PubMed
HIV-1 cell-to-cell transmission (Jurkat-to-Jurkat, 293T-to-Jurkat, PM1 to Jurkat, PBMCs to Jurkat) is inhibited by IFITM2 and this inhibition appears to be regulated by the IFITM protein C terminus, is IFITM-species specific and virus-strain specific PubMed
Knockdown of IFITM1/2/3 by siRNA enhances virus transmission to target cells and the production of virions in CD4+ T cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 interacts with IFITM2 PubMed
env HIV-1 Env processing from gp160 to gp120/41 is inhibited by IFITM2 PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with IFITM2 PubMed
env IFITM2/3 proteins are co-localize with HIV-1 Env in the cell interior, while surface-associated IFITM2/3 proteins are present at virus budding sites containing HIV-1 Gag and Env proteins in CD4+ T cells PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp120 interacts with IFITM2 PubMed
env HIV-1 Env processing from gp160 to gp120/41 is inhibited by IFITM2 PubMed
Nef nef IFITM2 significantly downregulates the expression of HIV-1 Nef by interfering with Tat/TAR-mediated expression PubMed
Pr55(Gag) gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 Gag in virus-producing cells and co-assemble with Gag into budding particles PubMed
gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
gag IFITM2/3 proteins are co-localize with HIV-1 Env in the cell interior, while surface-associated IFITM2/3 proteins are present at virus budding sites containing HIV-1 Gag and Env proteins in CD4+ T cells PubMed
gag IFITM2 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
Vif vif IFITM2 significantly downregulates the expression of HIV-1 Vif by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed
Vpr vpr HIV-1 Vpr upregulates the expression of IFITM1 in human monocyte-derived dendritic cells PubMed
vpr IFITM1, 2 or 3 marginally inhibit the entry of HIV-1 NL4-3 and SIV Mac into TZM-bl by measuring the cleavage of CCF2 by BlaM-Vpr that enters the cytoplasm together with viral cores PubMed
capsid gag IFITM1, IFITM2, and IFITM3 proteins (IFITMs) co-localize with HIV-1 CA in velocity gradients, indicating that IFITMs are virion-associated proteins PubMed
gag Endogenous IFITM1/2/3 proteins are upregulated in activated CD4+ T cells and incorporated into HIV-1 Gag/p24-associated virions during infection PubMed
gag IFITM2 significantly downregulates the expression of HIV-1 Gag and CA by interfering with both Rev/RRE- and Tat/TAR-mediated expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-alpha IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to interferon-beta IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
type I interferon signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon-induced transmembrane protein 2
Names
dispanin subfamily A member 2c
interferon-inducible protein 1-8D

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006435.2NP_006426.2  interferon-induced transmembrane protein 2

    See identical proteins and their annotated locations for NP_006426.2

    Status: VALIDATED

    Source sequence(s)
    BG164993, BG257141
    Consensus CDS
    CCDS41583.1
    UniProtKB/Swiss-Prot
    Q01629
    Related
    ENSP00000382714.4, ENST00000399817.8
    Conserved Domains (1) summary
    pfam04505
    Location:54119
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    308107..309410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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